CAV2
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Official Full Name
caveolin 2 -
Overview
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011] -
Synonyms
CAV2;caveolin 2;CAV;caveolin-2;caveolae protein, 20-kD;caveolin 2 isoform a and b
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
CAV2 involved in several pathways and played different roles in them. We selected most pathways CAV2 participated on our site, such as Endocytosis,Focal adhesion,Bacterial invasion of epithelial cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAV2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | VPS37D,DNM2B,FAM125A,IQSEC1,PLD1A,SNX2,CBLC,PARD6A,FOLR1,ARPC5LA |
| Bacterial invasion of epithelial cells | CLTC,CBLC,ACTG1,SEPT6,PIK3CB,SEPT12,ARPC1A,ARPC3,ARPC1B,SRC |
| Proteoglycans in cancer | PDPK1,FAS,AKT1,HOXD10,TP53,FGFR1,PXN,PLCG1,SDC4,HSPG2 |
| Focal adhesion | MET,VAV1,VWF,GRB2,COL1A1B,PDGFAB,MAPK9,COL4A6,PIK3R3B,ACTN4 |
Protein Function
CAV2 has several biochemical functions, for example, D1 dopamine receptor binding,protein binding,protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by CAV2 itself. We selected most functions CAV2 had, and list some proteins which have the same functions with CAV2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding, bridging | PPP2R3A,AMFR,SH2D1B,PPP4R2,TRIM17,FLRT3,TRIM5,MMS19,NUFIP1,SYNM |
| protein heterodimerization activity | POLE4,MYOG,ZHX1,TAF13,H2AFB3,ZHX3,OSTB,HIST1H4J,ATF2,H2-Q10 |
| scaffold protein binding | GRIN2A,SCN5A,NCK2,SHANK3,NLGN1,KRT15,NLGN3,ATP2B4,MDM2,KRT5 |
| protein homodimerization activity | QDPR,VEGFA,APOBEC3G,SDS,SYT10,BHLHA15,MAPK4,AMBP,NUDT21,SLC14A2 |
| protein binding | FGFRL1B,SYCE2,SPRED1,SEPT6,EHMT1,TCTN2,ANKRD17,RALGDS,FBXW9,TCF25 |
| protein kinase binding | HNRNPA0,SFN,LLGL1,SV2A,KIF14,PARK2,CENPJ,CCNB3,TNIP2,PTPRR |
| protein complex scaffold | HOMER1,CNOT1,AKAP9,WWC3,PKP2,WWC1,AKAP13,SMARCD1,AXIN1,SLC9A3R2 |
| D1 dopamine receptor binding | ATP1A3,AGTR1A,ARRB2,PTPN11,GNAS,DLG4,DRD3 |
Interacting Protein
CAV2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAV2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAV2.
EGFR;CAV1;DNAJA1;GOLGB1;q99ib8-pro_0000045602;ANXA2
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References
- Schubert, M; Panja, D; et al. Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. ACTA NEUROPATHOLOGICA 128:835-852(2014).
