CATSPER2
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Official Full Name
cation channel, sperm associated 2 -
Overview
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be a pseudogene. Additional splice variants have been described but their full-length nature has not been determined. -
Synonyms
CATSPER2;cation channel, sperm associated 2;cation channel sperm-associated protein 2;Cation channel sperm associated 2;Cation channel sperm associated protein 2;Catsper 2;MGC33346;Putative ion channel protein CATSPER2 variant 1;Putative ion channel protein CATSPER2 variant 2;Putative ion channel protein CATSPER2 variant 3;Sperm associated cation channel 2;Sperm ion channel
Recombinant Proteins
- Human
- Rat
- Mouse
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- His
- Avi
- Fc
Involved Pathway
CATSPER2 involved in several pathways and played different roles in them. We selected most pathways CATSPER2 participated on our site, such as Fertilization,Reproduction,Sperm Motility And Taxes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CATSPER2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Reproduction | IZUMO1,ZP2,HVCN1,TMEM146,Acr,ADAM21,ZP3,ADAM2,ADAM20,CATSPER1 |
| Fertilization | CATSPER1,ADAM2,IZUMO4,ADAM30,CATSPERG1,ADAM20,CATSPERB,ADAM21,ZP3,TMEM146 |
| Sperm Motility And Taxes | TMEM146,CATSPERG1,CATSPER3,HVCN1,CATSPER1,CATSPERG2,CATSPERB |
Protein Function
CATSPER2 has several biochemical functions, for example, calcium activated cation channel activity,calcium channel activity,ion channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CATSPER2 itself. We selected most functions CATSPER2 had, and list some proteins which have the same functions with CATSPER2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ion channel activity | CACNA1DA,TRPC4B,TRPM4C,TRPC4A,TPCN1,CLCNKB,TRPV5,GRIA2B,GABRA6A,FXYD2 |
| calcium channel activity | CACNG2B,ORAI1B,CACNG2A,CACNA1SB,TRPC2B,TPCN1,CHRNA9,SLC24A4,ITPR3,GRIN2A |
| calcium activated cation channel activity | CATSPER1,ANO6,TRPM4C,TRPM4,CALHM1,TMEM63C,TRPM5,ANO10,PKD2L1,TRPM4A |
| voltage-gated ion channel activity | KCNA6A,KCNJ16,CLIC3,TMEM37,KCNS3A,KCNH5,KCNK4,CALHM1,CACNA1BA,KCNJ1A.3 |
Interacting Protein
CATSPER2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CATSPER2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CATSPER2.
Ywhae
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