CASK
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Official Full Name
calcium/calmodulin-dependent serine protein kinase (MAGUK family) -
Overview
This gene encodes a calcium/calmodulin-dependent serine protein kinase. The encoded protein is a MAGUK;(membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded;protein is located at synapses in the brain. Mutations in this gene are associated with FG syndrome 4, mental;retardation and microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation.;Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
CASK;calcium/calmodulin-dependent serine protein kinase (MAGUK family);TNRC8, trinucleotide repeat containing 8;peripheral plasma membrane protein CASK;CAGH39;FGS4;LIN2;hCASK;protein lin-2 homolog;trinucleotide repeat containing 8;calcium/calmo
Recombinant Proteins
- Human
- Rat
- Mouse
- Rhesus macaque
- Insect Cells
- Sf9 Cells
- Mammalian Cells
- E.coli
- HEK293
- GST&His
- GST
- His
- Non
- Avi&Fc&His
- Flag
- DDK&Myc
Involved Pathway
CASK involved in several pathways and played different roles in them. We selected most pathways CASK participated on our site, such as Tight junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CASK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tight junction | CLDN11,MYL5,HCLS1,CLDN9,CLDN7,GNAI2A,SPTAN1,YES1,PPP2R1B,VMHC |
Protein Function
CASK has several biochemical functions, for example, ATP binding,calmodulin binding,guanylate kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CASK itself. We selected most functions CASK had, and list some proteins which have the same functions with CASK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | RAF1,SGK1,TESK2,ACVR2A,PRKCBA,BRAF,GRK1B,TTBK2,MAP3K9,TGFBR1B |
| calmodulin binding | ITPKC,RIT1,ARPP21,CTH,IQCB1,SMTNL1,CAMK2D2,MYH1B,SLC9A1,NDUFAF4 |
| ATP binding | BMPR2,CLK2A,ERCC3,MYH10,RUVBL1,DDX59,ERCC6L,CHD4A,TGFBR1,CERK |
| guanylate kinase activity | DLG1,GUK1A,MPP1,GUK1B,DLG4B,DLG4,TJP2,CARD11,MPP3,DLG2 |
| protein binding | CCDC141,LSM10,WDYHV1,ZKSCAN17,THAP10,C4BPB,SPHK1,HDAC2,CCDC43,ORAI1 |
| neurexin family protein binding | NLGN4A,NLGN1,SYTL3,NLGN4X,SYTL2,LRRTM2,NLGN3B,CPE,NLGN3,NLGN3A |
Interacting Protein
CASK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CASK here. Most of them are supplied by our site. Hope this information will be useful for your research of CASK.
LIN7A;CASKIN1;Nrxn1;RPH3A;SH2D4A;Caskin1
Resources
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References
- Patel, R; Al-Dossary, AA; et al. Plasma Membrane Ca2+-ATPase 4 in Murine Epididymis: Secretion of Splice Variants in the Luminal Fluid and a Role in Sperm Maturation. BIOLOGY OF REPRODUCTION 89:-(2013).
- Itoh, T; Ando, M; et al. Whiskey Congeners Suppress LPS/IFN gamma-Induced NO Production in Murine Macrophage RAW 264 Cells by Inducing Heme Oxygenase-1 Expression. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 60:12491-12500(2012).
