CARD9
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Official Full Name
caspase recruitment domain family, member 9 -
Overview
The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008] -
Synonyms
CARD9;caspase recruitment domain family, member 9;CANDF2;hCARD9;caspase recruitment domain-containing protein 9
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Wheat Germ
- Mammalian Cells
- E.coli
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- His&T7
- Myc&DDK
- Flag
Involved Pathway
CARD9 involved in several pathways and played different roles in them. We selected most pathways CARD9 participated on our site, such as NOD-like receptor signaling pathway,Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CARD9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NOD-like receptor signaling pathway | NFKBIAA,MAPK11,TAB2,HSP90AA1.2,NAIP1,CASP5,IKBKG,CASP1,MAP3K7IP3,NFKBIB |
| Tuberculosis | RAF1,MYD88,NFKB1,VDR,RELA,NFYB,CAMK2A,IL6,Cd209g,HLA-DPA1 |
Protein Function
CARD9 has several biochemical functions, for example, CARD domain binding,protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CARD9 itself. We selected most functions CARD9 had, and list some proteins which have the same functions with CARD9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CARD domain binding | RIPK2,C9orf89,CARD11,CARD14,NOD1,MAVS |
| protein binding | LPAR2,CEP76,AIPL1,SYTL1,SEPT5,CPS1,SSRP1,TMEM190,ALOX5AP,NRBP1 |
| protein homodimerization activity | ERCC5,CPNE1,ZHX3,MAP3K11,RPE,CD200,PRMT2,DSCAML1,SYNE1,GOLGA5 |
Interacting Protein
CARD9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CARD9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CARD9.
TRIM42;ZNF572;MEOX2;a8k932_human;a8kad6_human;386682
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References
- Desel, C; Werninghaus, K; et al. The Mincle-Activating Adjuvant TDB Induces MyD88-Dependent Th1 and Th17 Responses through IL-1R Signaling. PLOS ONE 8:-(2013).
- Zhao, XQ; Zhu, LL; et al. C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6 '-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-kappa B Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:30052-30062(2014).
