CAPNS1
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Official Full Name
calpain, small subunit 1 -
Overview
Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
CAPNS1;calpain, small subunit 1;30K;CANP;CDPS;CSS1;CANPS;CAPN4;CALPAIN4;calpain small subunit 1;CANP small subunit;calpain regulatory subunit;calpain, small polypeptide;calpain 4, small subunit (30K);calcium-dependent protease, small subunit;calcium-dependent protease small subunit 1;calcium-activated neutral proteinase small subunit
Recombinant Proteins
- Human
- Rat
- Mouse
- Wheat Germ
- Mammalian Cell
- E.coli
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- His&GST
- Non
- His&Fc&Avi
- Myc&DDK
- His&SUMO
Involved Pathway
CAPNS1 involved in several pathways and played different roles in them. We selected most pathways CAPNS1 participated on our site, such as Apoptosis Modulation and Signaling,Degradation of the extracellular matrix,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPNS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Degradation of the extracellular matrix | EMID2,TLL1,NID1,MMP17,ADAM8A,COL9A1,BMP1,MMP15,ADAMTS4,TLL2 |
| Integrin-mediated cell adhesion | CAPN3,CAPN9,TNS1,MYLK2,CAPN5,CAPN3A,SEPP1,CAPN10,MAPK6,MAPK4 |
| Extracellular matrix organization | COL10A1,MMP10,COL5A3B,MMP19,SERPINH1,TIMP2A,DMP1,MGC174152,PCOLCE2,LAMB1B |
| Apoptosis Modulation and Signaling | PTPN13,HN1,DIABLO,CASP2,BIK,DAXX,CRADD,BOK,PTRH2,BCL2L11 |
Protein Function
CAPNS1 has several biochemical functions, for example, calcium ion binding,calcium-dependent cysteine-type endopeptidase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPNS1 itself. We selected most functions CAPNS1 had, and list some proteins which have the same functions with CAPNS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-dependent cysteine-type endopeptidase activity | CAPN2,SOLH,GCA,CAPN9,SRI,PEF1,CAPN5,CAPN1,CAPN10,CAPN12 |
| protein binding | PITX2,RPL23A,CRK,JAK2,C1QTNF3,SYN1,UCN,IWS1,MIS18BP1,RBP5 |
| calcium ion binding | PCDH11Y,NECAB1,PCDH10,PCDHB2,VCANB,CASQ2,EFHA2,CALM4,PPP3R1,MMP25 |
Interacting Protein
CAPNS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPNS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPNS1.
CAPN1;CAPN2;AGTRAP;RASA1;TRAF5;CDK4;ARR3;STAT3;TERF1;ATP5J2;RAB1A
Resources
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References
- Hsu, CY; Henry, J; et al. Deimination of Human Filaggrin-2 Promotes Its Proteolysis by Calpain 1. JOURNAL OF BIOLOGICAL CHEMISTRY 286:23222-23233(2011).
- Shaikh, S; Samanta, K; et al. m-Calpain-mediated cleavage of Na+/Ca2+ exchanger-1 in caveolae vesicles isolated from pulmonary artery smooth muscle. MOLECULAR AND CELLULAR BIOCHEMISTRY 341:167-180(2010).
