CAPN9
-
Official Full Name
calpain 9 -
Overview
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is expressed predominantly in stomach and small intestine and may have specialized functions in the digestive tract. This gene is thought to be associated with gastric cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
CAPN9;calpain 9;GC36;nCL-4;calpain-9;new calpain 4;novel calpain large subunit-4;digestive tract-specific calpain
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
CAPN9 involved in several pathways and played different roles in them. We selected most pathways CAPN9 participated on our site, such as Integrin-mediated cell adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPN9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Integrin-mediated cell adhesion | CAPNS1,SEPP1,SEPP1A,MAPK4,MAPK6,CAPN3,TNS1,MYLK2,CAPN11,CAPN3A |
Protein Function
CAPN9 has several biochemical functions, for example, calcium ion binding,calcium-dependent cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPN9 itself. We selected most functions CAPN9 had, and list some proteins which have the same functions with CAPN9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | SYT3,ANXA4,PROCA,MELK,CDH16,SLC24A4,MEX3B,CDH11,MYL9,CBLC |
| calcium-dependent cysteine-type endopeptidase activity | PDCD6,GCA,SOLH,CAPN11,CAPN2,CAPN3A,CAPN10,CAPNS1A,CAPN13,SRI |
Interacting Protein
CAPN9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPN9 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPN9.
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References
- Soslau, G; Mason, C; et al. Intracellular matrix metalloproteinase-2 (MMP-2) regulates human platelet activation via hydrolysis of talin. THROMBOSIS AND HAEMOSTASIS 111:140-153(2014).
- Samanta, S; Ghoshal, A; et al. Sialoglycosylation of RBC in Visceral Leishmaniasis Leads to Enhanced Oxidative Stress, Calpain-Induced Fragmentation of Spectrin and Hemolysis. PLOS ONE 7:-(2012).
