CAPN12
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Official Full Name
calpain 12 -
Overview
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes a member of the calpain large subunit family. [provided by RefSeq, Jun 2012] -
Synonyms
CAPN12;calpain 12;calpain-12;CANP 12;calcium-activated neutral proteinase 12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CAPN12-0359H | Recombinant Human CAPN12 Protein, GST-Tagged | Wheat Germ | Human | GST |
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| CAPN12-390H | Recombinant Human CAPN12 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| CAPN12-5372Z | Recombinant Zebrafish CAPN12 | Mammalian Cell | Zebrafish | His |
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| Capn12-1951M | Recombinant Mouse Capn12 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| CAPN12-2817HF | Recombinant Full Length Human CAPN12 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 719 amino acids |
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| CAPN12-3242H | Recombinant Human CAPN12 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
CAPN12 involved in several pathways and played different roles in them. We selected most pathways CAPN12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CAPN12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
CAPN12 has several biochemical functions, for example, calcium ion binding,calcium-dependent cysteine-type endopeptidase activity,cysteine-type peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CAPN12 itself. We selected most functions CAPN12 had, and list some proteins which have the same functions with CAPN12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PPEF1,SRI,GUCA1B,PCDHGA10,SGCA,RASGRP1,THBS4,ITIH1,LDLRA,EFCAB2 |
| cysteine-type peptidase activity | PSD,SOLH,CTSSA,ZRANB1B,CASP6L1,CAPN2L,CTSJ,USP12A,CTSBA,CLCA5 |
| peptidase activity | TMPRSS5,TMPRSS12,PRSS28,CTSG,CTSM,AGA,MCPT8,PM20D1,FAP,DPEP3 |
| calcium-dependent cysteine-type endopeptidase activity | CAPN2L,CAPN2A,PDCD6,CAPN1B,CAPN1A,CAPN5,CAPN9,CAPN3,CAPN2B,PEF1 |
| hydrolase activity | PPM1LA,METAP2B,DDX39,SACM1LB,PTPRJA,CNOT6L,DCP1A,USP27X,HE1A,ATP2B1A |
Interacting Protein
CAPN12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAPN12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAPN12.
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References
- Comitato, A; Sanges, D; et al. Activation of Bax in Three Models of Retinitis Pigmentosa. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:3555-3561(2014).
- Samanta, S; Ghoshal, A; et al. Sialoglycosylation of RBC in Visceral Leishmaniasis Leads to Enhanced Oxidative Stress, Calpain-Induced Fragmentation of Spectrin and Hemolysis. PLOS ONE 7:-(2012).
