CAMKK1
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Official Full Name
calcium/calmodulin-dependent protein kinase kinase 1, alpha -
Overview
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. -
Synonyms
CAMKK1;calcium/calmodulin-dependent protein kinase kinase 1, alpha;calcium/calmodulin-dependent protein kinase kinase 1;CAMKKA;DKFZp761M0423;MGC34095;caMKK 1;caM-KK 1;caM-KK alpha;CAMKK alpha protein;caM-kinase kinase 1;caM-kinase IV kinase;ca
Recombinant Proteins
- Rat
- Human
- Mouse
- Sf9 Insect Cell
- Insect Cell
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- Insect (sf21)
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CAMKK1 involved in several pathways and played different roles in them. We selected most pathways CAMKK1 participated on our site, such as AMPK signaling pathway,Adipocytokine signaling pathway,Oxytocin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAMKK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adipocytokine signaling pathway | ACSL4B,NPY,LEPR,SLC2A1,MAPK8A,NFKBIAA,PRKAG3,PCK1,ACSBG2,ADIPOR1 |
| Oxytocin signaling pathway | PIK3R3,PIK3CG,MAP2K2,PRKACA,CALML5,PRKAB1,CD38,MEF2C,PRKAG1,PLA2G4F |
| AMPK signaling pathway | SLC2A4,CPT1A,IGF1,PFKM,PPP2CB,RHEB,RAB10,INS,G6PC2,INS1 |
| Alcoholism | GM14477,GNG7,HIST2H4A,GRIN3B,HIST1H4N,HRAS,GRIN2D,MAPK3,SOS1,GNB4 |
Protein Function
CAMKK1 has several biochemical functions, for example, ATP binding,calmodulin binding,calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CAMKK1 itself. We selected most functions CAMKK1 had, and list some proteins which have the same functions with CAMKK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | MAP6D1,DAPK2,MYH10,MKNK2,ADCY1,SPTBN1,CAMK1,MYO1F,SNTB2,NRGN |
| ATP binding | NLRP4E,ROCK2,ACTR8,NLRP9C,CDK1,KIF5C,CHST13,DYNC1LI1,ATP6V1BA,TRIP13 |
| calmodulin-dependent protein kinase activity | DCX,NETO2,MKNK2A,MAPKAPK5,PNCK,CAMK2G,CAMK2B1,MKNK2B,CAMKK2,CAMK2B |
| protein binding | FOXH1,CDCA7L,STRAP,SLC6A4,CXCR2,DAO,ZNF593,TBL3,YIPF2,TUB |
Interacting Protein
CAMKK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAMKK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CAMKK1.
YWHAH;HSP90AB1;b4dt77_human;H3F3B;BRINP1;NSA2;YWHAB;RPS10;CSNK1E;NTHL1;SAFB2;DDB1;C3orf17;KIAA2013;FBXL6;ELAC2
Resources
Research Area
Apoptosis Intracellular KinasesCalcium-binding Proteins and Related Molecules
Intracellular Kinases in the Akt Pathway
CaM Kinases
Related Services
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References
- Gergalova, G; Lykhmus, O; et al. alpha 7 nicotinic acetylcholine receptors control cytochrome c release from isolated mitochondria through kinase-mediated pathways. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 49:26-31(2014).
- Hidalgo, CG; Chung, CS; et al. The multifunctional Ca2+/calmodulin-dependent protein kinase II delta (CaMKII delta) phosphorylates cardiac titin's spring elements. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 54:90-97(2013).
