CALCRL
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Official Full Name
calcitonin receptor-like -
Overview
CRLR is a receptor for calcitonin gene related peptide type 1. The activity of CRLR is mediated by G proteins which activate adenylyl cyclase. CRLR expression has been reported in brain, lung, blood vessel, liver, and intestinal tract. ESTs have been isolated from B Cell/lung/testis, bone marrow, embryo, lung, and synovium libraries. -
Synonyms
CALCRL;calcitonin receptor-like;CRLR;CGRPR;calcitonin gene-related peptide type 1 receptor;CGRP type 1 receptor;calcitonin receptor-like receptor
Recombinant Proteins
- Human
- Rat
- Chicken
- Xenopus laevis
- Bovine
- Oncorhynchus gorbuscha (Pink salmon) (Salmo gorbuscha)
- Mus musculus
- Paralichthys olivaceus (Bastard halibut) (Hippoglossus olivaceus)
- Sus scrofa (Pig)
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- Wheat Germ
- Mammalian Cells
- E.coli
- HEK293
- In Vitro Cell Free System
- Non
- GST
- His
- Flag
- Avi
- Fc
Involved Pathway
CALCRL involved in several pathways and played different roles in them. We selected most pathways CALCRL participated on our site, such as Calcitonin-like ligand receptors,Class B/2 (Secretin family receptors),Endothelin, which may be useful for your reference. Also, other proteins which involved in the same pathway with CALCRL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G alpha (s) signalling events | CRHR2,PTHLHA,PTHLH,ADCYAP1B,RLN3A,RLN3,GCGB,CALCA,NPSR1,CGA |
| GPCRs, Class B Secretin-like | ELTD1,ADCYAP1R1,CRHR1,EMR1,CRHR2,EMR2,LPHN1,CD97 |
| Calcitonin-like ligand receptors | CALCB,RAMP3,ADM,ADM2,CALCA,RAMP2,ADM2A,RAMP1 |
| Endothelin | EDNRA,CALCA,ECE1,EDNRB,RAMP1,EDN1,CNN1,MYL1 |
| GPCR downstream signaling | PLEKHG2,OPN1LW1,NMBB,CXCR6,MGLL,MLN,NPSR1,MCF2L,LPAR1,OR2AP1 |
| Class B/2 (Secretin family receptors) | ADM2A,CALCB,ADCYAP1B,RAMP2,GCGB,CRHR1,ADM,PTHRP2,GHRH,PTH |
| Neuroactive ligand-receptor interaction | CHRM5A,P2RY6,TAAR12E,MC5RB,GCGR,MLNR,GLP1R,ADORA1,P2RX8,HTR2B |
| GPCR ligand binding | EDN3,CYSLTR1,CCRL2,FZD10,CCL35.2,ADORA2A,SSTR4,PYY,PNOCB,FFAR3 |
Protein Function
CALCRL has several biochemical functions, for example, G-protein coupled receptor activity,adrenomedullin receptor activity,calcitonin gene-related peptide receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CALCRL itself. We selected most functions CALCRL had, and list some proteins which have the same functions with CALCRL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcitonin receptor activity | CALCR,RAMP1,CALCRLA |
| protein transporter activity | VPS26B,ZFYVE16,IPO9,KPNA3,KPNA2,IPO13,RANBP6,TIMM10,ARFGAP3,DSCR3 |
| G-protein coupled receptor activity | PRLHR2B,TAAR19P,TM2D1,GPR31,OR51B4,TAAR14D,OR13A1,OLFR480,GPR124,TAAR12I |
| adrenomedullin receptor activity | GPR182 |
| protein binding | AGTR1A,FOSL1,ZFP36,MC2R,FGFR3,BCAP31,NEK11,IMPDH2,WRN,UBE2V2 |
| calcitonin gene-related peptide receptor activity | CRCP |
Interacting Protein
CALCRL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CALCRL here. Most of them are supplied by our site. Hope this information will be useful for your research of CALCRL.
RAMP2;ADM;CALCA;CALCA;RAMP1
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References
- Vecsei, L; Szok, D; et al. CGRP antagonists and antibodies for the treatment of migraine. EXPERT OPINION ON INVESTIGATIONAL DRUGS 24:31-41(2015).
- Edvinsson, L; Warfvinge, K; et al. CGRP Receptor Antagonism and Migraine Therapy. CURRENT PROTEIN & PEPTIDE SCIENCE 14:386-392(2013).
