CAD
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Official Full Name
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase -
Overview
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. -
Synonyms
CAD;carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase;CAD protein;CAD trifunctional protein;multifunctional protein CAD
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- His
- His&Fc&Avi
- N-His&C-Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CAD-10649H | Recombinant Human CAD, His-tagged | E.coli | Human | His | C-term-350a.a. | |
| CAD-49H | Recombinant Human CAD protein, His-tagged | E.coli | Human | His | Arg87~Lys323 | |
| CAD-1966Z | Recombinant Zebrafish CAD | Mammalian Cells | Zebrafish | His |
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| CAD-2634M | Recombinant Mouse CAD Protein | Mammalian Cells | Mouse | His |
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| CAD-1179M | Recombinant Mouse CAD Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| CAD-1179M-B | Recombinant Mouse CAD Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CAD-2322H | Recombinant Human CAD protein, His-tagged | E.coli | Human | His | 1456-1846aa |
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| CAD-5857H | Recombinant Human CAD protein, His&Myc-tagged | E.coli | Human | N-His&C-Myc | 1456-1846aa |
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Involved Pathway
CAD involved in several pathways and played different roles in them. We selected most pathways CAD participated on our site, such as Pyrimidine metabolism,Alanine, aspartate and glutamate metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CAD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyrimidine metabolism | UCKL1,ZNRD1,ENTPD4,POLR2J3,POLR2J2,CANT1B,UPP2,NT5C1B-RDH14,POLA2,UMPS |
| Metabolic pathways | ALDH3A2,CEPT1,PDHA2,B3GNT3,ATP6V0A1A,EXTL3,ADSL,ALOX12E,DGKZ,SMS |
| Alanine, aspartate and glutamate metabolism | ASNS,GLS2,RIMKLB,GPT2,ADSL,IL4I1,ADSS,ASL,ADSSL,GLS |
Protein Function
CAD has several biochemical functions, for example, ATP binding,aspartate binding,aspartate carbamoyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CAD itself. We selected most functions CAD had, and list some proteins which have the same functions with CAD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbamoyl-phosphate synthase (ammonia) activity | CPS1 |
| protein kinase activity | MAP3K4,STK26,RPS6KAL,DYRK1A,SRPK1B,MAP4K3,NIM1,EPHA4,DCLK2,AKT3A |
| identical protein binding | PACSIN2,MUL1A,RB1,MICALL1,AKT1,KCTD13,KHDC1B,NUFIP1,FHIT,BCAT1 |
| carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity | CPS1 |
| ATP binding | CDK12,CAMK1DB,GLUD1,RUNX2B,PRKG2,NPR1A,UBA6,CDK14,SEPHS2,AFG3L2 |
| zinc ion binding | DEF8,LIMA1,CRIP2,RBM4.1,KCMF1,HHIP,TNFAIP3,ZFYVE19,PHF23B,MT1M |
| enzyme binding | CYB5A,PGR,TAF10,CD4,RAD9A,PIAS1,NCOA1,RPS3,PCCA,LGALS9 |
Interacting Protein
CAD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CAD here. Most of them are supplied by our site. Hope this information will be useful for your research of CAD.
ILK;NFKB2;NFKBIE;MAP3K7;TNFRSF1A;TNFRSF1B;YWHAZ;NFKB2;RELB;RELA;TRAF2;MAP3K1;RIPK1;TRADD;SMAD2;MAP3K14;MAP3K3;TAB2
Resources
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References
- Li, HN; Yan, JR; et al. Construction of a biotinylated cameloid-like antibody for lable-free detection of apolipoprotein B-100. BIOSENSORS & BIOELECTRONICS 64:111-118(2015).
- Fenoglio, C; Albicini, F; et al. Renal Fibrogenesis and Platinum Compounds in a Rat Model: A Novel Pt (II) Complex vs. Cisplatin. ANTICANCER RESEARCH 35:739-751(2015).
