CACNB3
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Official Full Name
calcium channel, voltage-dependent, beta 3 subunit -
Overview
This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of;five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also;play a role in the regulation of transcription factors and calcium transport. -
Synonyms
CACNB3;calcium channel, voltage-dependent, beta 3 subunit;voltage-dependent L-type calcium channel subunit beta-3;CAB3;CACB3_HUMAN;CACNLB3;Calcium Channel Voltage Dependent Beta 3 Subunit;Calcium channel voltage-dependent subunit beta 3;Calcium channel subunit beta 3;CACH3B
Recombinant Proteins
- Human
- Rat
- Rhesus macaque
- Mouse
- Wheat Germ
- Mammalian Cell
- Mammalian cells
- HEK293
- In Vitro Cell Free System
- HEK293T
- GST
- His
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
CACNB3 involved in several pathways and played different roles in them. We selected most pathways CACNB3 participated on our site, such as MAPK signaling pathway,Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with CACNB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cardiac muscle contraction | ATP1A3,ATP1B2B,COX5B,CACNG6A,ATP1B2,TNNC1A,COX7A1,CACNB4,UQCRC2A,CACNA1SB |
| Dilated cardiomyopathy | CACNG7,LAMA2,SLC8A1,DAG1,PRKACA,ITGB4,CACNA2D2,TTN,TNF,PRKACB |
| Oxytocin signaling pathway | CACNB4,CALML3,ACTB,PIK3R3,PPP3CB,PPP1CA,PRKAA1,PLCB2,PRKAG2,PTGS2 |
| Hypertrophic cardiomyopathy (HCM) | TNF,ITGB7,ITGA2,SGCB,ITGA7,Itga10&Itgb1,ITGB4,PRKAA1,CACNG6,CACNG1 |
| Adrenergic signaling in cardiomyocytes | PPP2R2C,ACTC1,TNNC1B,AKT2,MYH15,PPP2R5CB,ATP1B2A,CREB3L2,FXYD2,CACNB4 |
| MAPK signaling pathway | FGFR1A,FLNC,MAPK9,CACNB4A,FGF1B,ELK1,GNG12,MAPT,NF1,TAOK1 |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | CACNA2D1,ACTN3,SGCA,LMNA,CACNG6,CACNA2D2,CTNNA1,CACNG3,CACNA2D3,ITGA8 |
Protein Function
CACNB3 has several biochemical functions, for example, high voltage-gated calcium channel activity,protein kinase binding,contributes_to voltage-gated calcium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CACNB3 itself. We selected most functions CACNB3 had, and list some proteins which have the same functions with CACNB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | CD4,CD3E,DNM2,SOCS1,CCND1,NBEA,ADAM10,CCND2,CDC42,CADPS |
| high voltage-gated calcium channel activity | CACNA1BA,CACNB1,CACNB3A,CACNB4A,CACNA1B,CACNA1C,CACNA1DA,CACNA1SB,CACNB4B,CACNB2A |
| contributes_to voltage-gated calcium channel activity | CACNA2D1,CACNB4 |
Interacting Protein
CACNB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CACNB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CACNB3.
FASLG;SYT1
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References
- Murakami, M; Nakagawasai, O; et al. Modified behavioral characteristics following ablation of the voltage-dependent calcium channel beta 3 subunit. BRAIN RESEARCH 1160:102-112(2007).
- Endoh, T; et al. Characterization of modulatory effects of postsynaptic metabotropic glutamate receptors on calcium currents in rat nucleus tractus solitarius. BRAIN RESEARCH 1024:212-224(2004).
