C1QTNF4
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Official Full Name
C1q and tumor necrosis factor related protein 4 -
Overview
Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Multiple isoforms of mouse CTRP4 have been reported. -
Synonyms
C1q and tumor necrosis factor related protein 4;C1QTNF4;Complement C1q tumor necrosis factor related protein;ZACRP4
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Mammalian Cell
- HEK293
- HEK293T
- His
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| C1QTNF4-1362H | Recombinant Human C1QTNF4 | Mammalian Cell | Human | His |
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| C1QTNF4-2460Z | Recombinant Zebrafish C1QTNF4 | Mammalian Cell | Zebrafish | His |
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| C1QTNF4-2571M | Recombinant Mouse C1QTNF4 Protein | Mammalian Cell | Mouse | His |
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| C1QTNF4-1138M | Recombinant Mouse C1QTNF4 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| C1QTNF4-1138M-B | Recombinant Mouse C1QTNF4 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| C1qtnf4-1911M | Recombinant Mouse C1qtnf4 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| C1QTNF4-2567H | Recombinant Human C1QTNF4 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| C1QTNF4-2567H-B | Recombinant Human C1QTNF4 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| C1QTNF4-550H | Recombinant Human C1QTNF4 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
C1QTNF4 involved in several pathways and played different roles in them. We selected most pathways C1QTNF4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with C1QTNF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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Protein Function
C1QTNF4 has several biochemical functions, for example, cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by C1QTNF4 itself. We selected most functions C1QTNF4 had, and list some proteins which have the same functions with C1QTNF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | GDF5,BMP6,Il1f6,MIF,LFT1,BMP10,CXCL9,CSF2,IL34,IL36B |
Interacting Protein
C1QTNF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1QTNF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of C1QTNF4.
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References
- Xin, YP; Lyu, XD; et al. Elevated circulating levels of CTRP1, a novel adipokine, in diabetic patients. ENDOCRINE JOURNAL 61:841-847(2014).
- Byerly, MS; Petersen, PS; et al. C1q/TNF-related Protein 4 (CTRP4) Is a Unique Secreted Protein with Two Tandem C1q Domains That Functions in the Hypothalamus to Modulate Food Intake and Body Weight. JOURNAL OF BIOLOGICAL CHEMISTRY 289:4055-4069(2014).
