BUB3
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Official Full Name
budding uninhibited by benzimidazoles 3 homolog -
Overview
The Mitotic Checkpoint Complex (MCC), which contains Bub1, Bub1b, Bub3, Mad2, and Cdc20, controls chromosome segregation and monitors kinetochore-microtubule interactions. During mitosis, the MCC complex inhibits the ubiquitin ligase activity of the Anaph -
Synonyms
BUB3;budding uninhibited;BUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog;mitotic checkpoint protein BUB3;BUB3L;mitotic checkpoint component;budding uninhibited by benomyl;BUB3 budding uninhibited by benzimidazoles 3 homolog;hBUB3
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
BUB3 involved in several pathways and played different roles in them. We selected most pathways BUB3 participated on our site, such as Cell cycle,HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with BUB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | FZD8,NFATC1,WNT9A,RANBP3,KAT2B,ATF1,PPP3CA,CD3E; CD3D,HLA-DRA,PDGFRA |
| Cell cycle | CENPN,MAPRE1B,BRCC3,ANKLE2,GINS3,CDC25A,PTTG2,RBBP8,CDC23,ORC3 |
Protein Function
BUB3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BUB3 itself. We selected most functions BUB3 had, and list some proteins which have the same functions with BUB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DPM1,NAT10,TMEM86B,AXIN2,COMTD1,SORCS1,FOXO3B,SCOC,FAM107A,SPG7 |
Interacting Protein
BUB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BUB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BUB3.
BUB1B;BUB1;ZNF207;sspH2;PSTPIP1;DYNLT3
Resources
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References
- Orjalo, AV; Arnaoutov, A; et al. The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly. MOLECULAR BIOLOGY OF THE CELL 17:3806-3818(2006).
- Yan, CL; Wu, W; et al. Benzo[a]pyrene treatment leads to changes in nuclear protein expression and alternative splicing. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS 686:47-56(2010).
