BRCA2
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Official Full Name
breast cancer 2, early onset -
Overview
BRCA2 (Breast Cancer 2 susceptibility protein) is a protein that in humans is encoded by the BRCA2 gene. BRCA2 orthologs have been identified in most mammals for which complete genome data are available. BRCA2 belongs to the tumor suppressor gene family and the protein encoded by this gene is involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double strand breaks. -
Synonyms
BRCA2;breast cancer 2, early onset;FACD, FANCD, FANCD1, Fanconi anemia, complementation group D1;breast cancer type 2 susceptibility protein;BRCA1/BRCA2 containing complex;subunit 2;BRCC2;FAD;FAD1;fanconi anemia group D1 protein;breast cancer 2
Recombinant Proteins
- Human
- Mouse
- Chicken
- Zebrafish
- Rat
- Insect Cells
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- GST
- His
- Non
- T7
- Avi
- Fc
- Flag
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| BRCA2-232H | Recombinant Human BRCA2, His & GST-tagged | Insect Cells | Human | GST&His | Met1-Val314 |
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| BRCA2-2480M | Recombinant Mouse BRCA2 Protein | Mammalian Cells | Mouse | His |
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| BRCA2-27673TH | Recombinant Human BRCA2 | Wheat Germ | Human | Non | 100 amino acids |
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| BRCA2-5849C | Recombinant Chicken BRCA2 | Mammalian Cells | Chicken | His |
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| BRCA2-6156Z | Recombinant Zebrafish BRCA2 | Mammalian Cells | Zebrafish | His |
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| BRCA2-6856H | Recombinant Human BRCA2 protein, His & T7-tagged | E.coli | Human | His&T7 | Lys2308~His2537 |
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| Brca2-6857M | Recombinant Mouse Brca2 protein, His & T7-tagged | E.coli | Mouse | His&T7 | Glu2990~Ala3232 |
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| Brca2-6858R | Recombinant Rat Brca2 protein, His & T7-tagged | E.coli | Rat | His&T7 | Ala2913~Pro3151 |
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| BRCA2-0792H | Recombinant Human BRCA2 Protein (Lys2308-His2537), N-His tagged | E.coli | Human | His | Lys2308-His2537 |
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| BRCA2-1084M | Recombinant Mouse BRCA2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| BRCA2-1084M-B | Recombinant Mouse BRCA2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| BRCA2-182H | Recombinant Human breast cancer 2, early onset Protein, Flag tagged | E.coli | Human | Flag | 3280-3418aa |
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Involved Pathway
BRCA2 involved in several pathways and played different roles in them. We selected most pathways BRCA2 participated on our site, such as Homologous recombination,Fanconi anemia pathway,Pathways in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRCA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | RPA3,POLN,C19orf40,REV1,RMI1,USP1,EME1,USP36,UBE2T,PALB2 |
| Homologous recombination | XRCC3,POLD4,MUS81,FUZ,XRCC2,NBN,RPA3,POLD1,EME1,RAD51 |
| Pathways in cancer | TCF7,APC2,TPM3,WNT7B,CCDC6,TRAF3,FGF8,CBL,TRAF1,AKT2 |
| Pancreatic cancer | SMAD4,BRAF,PIK3CD,TGFB3,MAPK1,CCND1,CASP9,PIK3CG,MAPK3,RAD51 |
Protein Function
BRCA2 has several biochemical functions, for example, H3 histone acetyltransferase activity,H4 histone acetyltransferase activity,gamma-tubulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRCA2 itself. We selected most functions BRCA2 had, and list some proteins which have the same functions with BRCA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protease binding | KIT,TTN,Cstb,ITGAV,BCL10,TIMP4,FLOT1,Serpina1b,SERPINE1,HSPD1 |
| NOT histone acetyltransferase activity | BAZ1A,EDF1,ARRB1 |
| H3 histone acetyltransferase activity | ELP3,KAT2A |
| single-stranded DNA binding | RBMS1,SWSAP1,CDC45,SSBP3B,RAD51,SSBP2,NUP35,CSDA,ERCC4,MLH3 |
| gamma-tubulin binding | CEP57,B9D2,PDE4B,NDN,TUBGCP5,OFD1,LYN,MARK4,SPATC1,TUBGCP2 |
| protein binding | TBL1XR1,EFEMP2,TRPC2,DR1,SPTLC1,PTGES2,RAD50,TFR2,NPDC1,SNRPD3 |
| H4 histone acetyltransferase activity | HAT1,ELP3,NAA50,NAA60,NAT15 |
Interacting Protein
BRCA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRCA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRCA2.
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References
- Le Cigne, A; Menil-Philippot, V; et al. Transient expression of RAD51 in the late G2-phase is required for cell cycle progression in synchronous Physarum cells. GENES TO CELLS 19:755-765(2014).
- Ren, X; Yan, T; et al. Nanosheet Au/Co3O4-based ultrasensitive nonenzymatic immunosensor for melanoma adhesion molecule antigen. BIOSENSORS & BIOELECTRONICS 58:345-350(2014).
