BRAP

  • Official Full Name

    BRCA1 associated protein

  • Overview

    The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]

  • Synonyms

    BRAP;BRCA1 associated protein;IMP;BRAP2;RNF52;BRCA1-associated protein;RING finger protein 52;galectin-2-binding protein;renal carcinoma antigen NY-REN-63;impedes mitogenic signal propagation

Recombinant Proteins

  • Mouse
  • Chicken
  • Rhesus macaque
  • Zebrafish
  • Human
  • Mammalian Cells
  • E.coli
  • HEK293
  • Yeast
  • E. coli
  • His
  • Non
  • Avi
  • Fc
  • GST

    Involved Pathway

    BRAP involved in several pathways and played different roles in them. We selected most pathways BRAP participated on our site, such as Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ras signaling pathway FGF5,SHC1,VEGFA,ABL2,FGF8,IKBKB,RAC2,Pdgfa&Pdgfb,PIK3R1,FIGF

    Protein Function

    BRAP has several biochemical functions, for example, identical protein binding,ligase activity,nuclear localization sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRAP itself. We selected most functions BRAP had, and list some proteins which have the same functions with BRAP. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity STUB1,RBCK1,RNF144A,GLULB,RNF144AB,GLULC,PIAS3,RNF152,RNF38,RNF114
    ubiquitin binding HSPB1,VPS36,RNF168,OTUB1,FAF2,OTUB2,TRIM32,SIRT2,UCHL3,UBE2NB
    zinc ion binding PDLIM1,FANCL,ZMYM5,DPYS,TRIM58,S100A6,RXRA,PCGF3,S100A9,MT1X
    ubiquitin protein ligase activity MED23,ASB4,HERC2,UBE2S,RNF165,CDC34B,TRIP12,AMFR,PDZRN4,ITCH
    identical protein binding RYR2,VWA2,TTN,TMEM173,CNTN2,C1QL4,SF1,DHX8,NUFIP1,IGF2R
    nucleotide binding ACTR1,CNGA4,RBMY1F,DIRAS1A,MYO10,RBM38,GMPPAA,UCK2A,RERGLA,DGKAA
    nuclear localization sequence binding KPNA4,KPNB3,KPNA6,IPO4,IPO5,IPO13,TNPO1,TNPO3,KPNA5,NUP214
    ubiquitin-protein transferase activity RNF220,RC3H2,RNF11,PEX2,ZNRF1,MGRN1,CDC34,TRIM71,ITCH,UBE2Q2
    protein binding TSC22D4,CTDSP1,HNRNPA2B1,STON2,CARD10,KLRG1,CAPN1,TWF2,ISCA2,IFNA4

    Interacting Protein

    BRAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRAP here. Most of them are supplied by our site. Hope this information will be useful for your research of BRAP.

    HRAS;AKAP3;BRCA1;PHLPP1;PHLPP1;PHLPP1;Dnmt1;KSR1;ATMIN;APOA1;UBB;UBC

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