BRAP
-
Official Full Name
BRCA1 associated protein -
Overview
The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008] -
Synonyms
BRAP;BRCA1 associated protein;IMP;BRAP2;RNF52;BRCA1-associated protein;RING finger protein 52;galectin-2-binding protein;renal carcinoma antigen NY-REN-63;impedes mitogenic signal propagation
Recombinant Proteins
- Mouse
- Chicken
- Rhesus macaque
- Zebrafish
- Human
- Mammalian Cells
- E.coli
- HEK293
- Yeast
- His
- Non
- Avi
- Fc
Involved Pathway
BRAP involved in several pathways and played different roles in them. We selected most pathways BRAP participated on our site, such as Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | GNG5,GRIN1,Pdgfa&Pdgfb,PLD1,FGF3,IGF1,PRKACA,PIK3CD,SHC1,RALB |
Protein Function
BRAP has several biochemical functions, for example, identical protein binding,ligase activity,nuclear localization sequence binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRAP itself. We selected most functions BRAP had, and list some proteins which have the same functions with BRAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | DTX3L,SIAH1,HERC5,UBOX5,TRIM38,RNF144AA,MGRN1A,SIAH2L,BIRC7,SIAH1A |
| ubiquitin binding | IDE,UBXN11,USP16,FAM125A,C36E6.2,UBE2N,BCL10,USP5,SMAD3,TRIM32 |
| ubiquitin protein ligase activity | HECTD1,UBE2H,RNF175,NEURL3,RNF25,PJA2,TRIM59,SYVN1,ITCH,UBE2KB |
| protein binding | NUB1,LGR4,GTF2I,DUSP5,CSTF3,SH3PXD2A,C20orf195,PRDX4,MIEN1,RHBDL1 |
| zinc ion binding | ZNF3,PHF20L1,TRIM28,ZKSCAN5,DHH,TRIM16,L3MBTL4,RORAA,KDM5B,MIB2 |
| nuclear localization sequence binding | KPNA5,KPNA6,KPNA7,TNPO2,RANBP6,IPO5,IPO13,KPNB3,TNPO3,KPNA1 |
| ubiquitin-protein transferase activity | ZNRF1,UBR5,BIRC7,TRAF4,MARCH4,FBXL14B,SMURF2,SIAH1,HECTD3,ARIH1 |
| identical protein binding | STAC3,SRI,NDE1,TFRC,USP15,VIM,HOMER1,YWHAZ,TPD52L1,PYDC3 |
| nucleotide binding | RAVER1,SRSF9,ELAVL4,BMPR1BB,HDGF,EIF3B,RAC1A,U2AF2B,NT5C1AA,DYNC2H1 |
Interacting Protein
BRAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRAP here. Most of them are supplied by our site. Hope this information will be useful for your research of BRAP.
HRAS;AKAP3;BRCA1;PHLPP1;PHLPP1;PHLPP1;Dnmt1;KSR1;ATMIN;APOA1;UBB;UBC
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