BORA
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Official Full Name
bora, aurora kinase A activator -
Overview
BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation,;spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 (PubMed;16890155)). -
Synonyms
BORA;bora, aurora kinase A activator;C13orf34, chromosome 13 open reading frame 34;protein aurora borealis;FLJ22624;Aurora borealis;BORA_HUMAN;C13orf34;Chromosome 13 open reading frame 34;HsBora;RP11-342J4.2;OTTHUMP00000018495
Recombinant Proteins
- Rat
- Zebrafish
- Mouse
- Chicken
- Human
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- His&Fc&Avi
- GST
Involved Pathway
BORA involved in several pathways and played different roles in them. We selected most pathways BORA participated on our site, such as Cell Cycle,Cell Cycle, Mitotic,G2/M Transition, which may be useful for your reference. Also, other proteins which involved in the same pathway with BORA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of PLK1 Activity at G2/M Transition | TCTN2 |
| Cell cycle | ATM,RAD9B,CENPP,SUN1,MIS18A,MCM9,DCTN3,NUPL2,FZR1,CENPE |
| G2/M Transition | MYBL2,MAPRE1B,DCTN2,ACTR1A,CEP57,LIN37,PCM1,TCTN2,LIN9,DCTN1 |
| Cell Cycle, Mitotic | CEP290,ENSA,E2F2,HIST2H3C,MAPRE1A,NCAPD2,NIPBL,NEDD1,MYCA,LMNB1 |
| Mitotic G2-G2/M phases | TCTN2,TUBGCP5,LIN37,LIN52,TUBGCP2,CDK11B,TUBGCP3,TUBGCP4,TUBG2,CDK11A |
| PLK1 signaling events | PLK1S1,ECT2,ERCC6L,TCTN2,TPT1,TPX2,NDC80,SPC24 |
Protein Function
BORA has several biochemical functions, for example, protein binding,protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BORA itself. We selected most functions BORA had, and list some proteins which have the same functions with BORA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | FZD5,PTPRR,PTPN2,CCNK,FOXO3,RPS6,CCNB1,CD3E,NME2,AKAP1 |
| protein binding | IL1RN,HCST,MS4A1,NUTF2,NAT2,CTAGE5,CELSR1,ATF6,KHDC1B,SENP6 |
Interacting Protein
BORA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BORA here. Most of them are supplied by our site. Hope this information will be useful for your research of BORA.
Plk1;BTRC;FGFR3;FEZ1;PLK1;RNF219;NGDN;PIBF1
Resources
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References
- van de Waterbeemd, M; Lossl, P; et al. Simultaneous Assessment of Kinetic, Site-Specific, and Structural Aspects of Enzymatic Protein Phosphorylation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53:9660-9664(2014).
- Lee, JK; Kang, IC; et al. Analysis of Plk1-Bora interaction using a Protein Chip system. BIOCHIP JOURNAL 7:151-155(2013).
