BIRC3

What is BIRC3 Protein?

BIRC3, which stands for baculoviral IAP repeat-containing protein 3, is part of a group called inhibitor of apoptosis proteins (IAPs). These proteins are like the guardians that stop cells from dying too soon. In normal situations, BIRC3 is pretty helpful, giving cells a hand during tough times. However, in cancer, BIRC3 can become a problem. It might help cancer cells dodge death and resist treatments. This makes BIRC3 a hot topic for researchers trying to find new ways to tackle cancer, as it could be a key to developing more effective therapies.

What is the Function of BIRC3 Protein?

BIRC3 is a protein that helps cells escape apoptosis, the process of programmed cell death. In normal situations, it supports cell survival under stress. But in cancer, it can let tumor cells avoid dying, even when they're damaged. This makes it an important focus for cancer research. Scientists are exploring ways to target BIRC3 to encourage cancer cells to die, aiming for more effective treatments.

BIRC3 Related Signaling Pathway

BIRC3 is involved in some key signaling pathways that help cells decide whether to live or die. One of the main pathways it participates in is the NF-kB pathway, which plays a role in regulating immune response and cell survival. When BIRC3 is active, it can help keep this pathway turned on, allowing cells to avoid programmed death. In normal cells, this can be useful for surviving stress. However, in cancer, BIRC3 can hijack this system to help tumor cells resist death, even when they should be shutting down. This connection makes BIRC3 a target of interest in research, with scientists working on ways to block its action to potentially stop cancer cells from growing.

BIRC3 Related Diseases

BIRC3 is a gene that codes for baculoviral IAP repeat containing 3, a protein known for its role in inhibiting cell death and regulating immune responses. When malfunctions or mutations occur in this gene, it may lead to a variety of health issues. Notably, it's associated with cancer types, including leukemia and lymphoma. These conditions often involve the uncontrolled division of cells due to insufficient apoptosis, or programmed cell death, partly because BIRC3 fails to perform its job. Moreover, BIRC3 is linked to certain autoimmune diseases, as it influences immune cell survival. This gene's activity needs to be balanced because too much or too little can tip the scale towards disease. Scientists are keenly studying BIRC3 to develop better treatments for these related diseases.

Bioapplications of BIRC3

BIRC3's role in the body is like a manager for cell life, playing a big part in how cells survive or meet their end. This makes it a major player not just in disease but in some pretty cutting-edge applications, too. In the world of bioengineering and medical research, people are looking at ways to harness BIRC3 for therapies. Imagine tweaking its activity to improve treatments for diseases where cells don’t die when they should, like in certain cancers. There's also talk about using it to help modulate immune responses, which could be a game changer for autoimmune diseases or in the realm of organ transplants. The potential is huge, and researchers are excited to explore how manipulating BIRC3 can lead to new therapies or even innovations in regenerative medicine. It's like they're trying to turn a key player in health challenges into a tool for healing and recovery.

Case Study 1: Wu Q. et al. Int J Mol Sci. 2021

Stemness reprogramming in glioblastoma (GBM) drives its deadliness, so targeting the root causes is crucial. We've found that BIRC3 plays a surprising role in GBM's self-renewal and resistance to treatment. It influences stemness by affecting BMP4 signaling. When BIRC3 is absent, BMP4 levels rise, preventing this stemness change. In experiments, silencing BIRC3 in GBM models reduced tumor growth, pointing to its key role in tumor diversity and progression.

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  Fig1. Protein expression of BIRC3 in U251 and U87 GBM cells.
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  Fig2. Protein expression of SMAD1, SMAD5 and phosphorylated SMAD1/5 in U251/U87 control, BIRC3-OE and BIRC3-KO cells.

Case Study 2: Jiang X. et al. Cancer Sci. 2017

Studies often show mixed results on the role of inhibitor of apoptosis proteins (IAPs) in cancer. One well-studied IAP, cIAP2, hadn't been explored in human gallbladder cancer (GBC) until now. We used various assays and techniques to analyze cIAP2 levels and found it was higher in GBC tissues, linking it to worse patient outcomes. cIAP2 acts as a lymphangiogenic factor, promoting lymph node metastasis in GBC through the NF-κB pathway, which we validated with both cell and animal models.

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  Fig3. The expression of cIAP2 protein in NOZ and SGC‐996 cells was suppressed by siRNA targeted to cIAP2.
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  Fig4. In the cytoplasm protein lysates, NOZ and SGC‐996 cells transduced with LV‐shcIAP2 targeting cIAP2.

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  Fig1. IAPs function as E3 ligases in TNFR1-mediated activation of NF-κB. (Mads Gyrd-Hansen, 2010)
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  Fig2. IAP proteins play prominent roles in NF-κB signaling and cell death pathways. (Longchuan Bai, 2014)

BIRC3 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC3 itself. We selected most functions BIRC3 had, and list some proteins which have the same functions with BIRC3. You can find most of the proteins on our site.

Function	Related Protein
ubiquitin-protein transferase activity	MALT1,FBXO2,MGRN1,RNF139,FBXO30A,ARIH1L,FBXO40.1,UBR4,RNF4,UBE2Q2
zinc ion binding	ANKIB1,PCGF3,CBLB,BTR09,KDM4A,CHD4,USP49,CCS,PTPN1,ADAM23
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	MT3,ARRB1,BIRC8,TNFSF14,DPEP1,PRDX5,NOL3,TFAP2B,XIAP,SNCA
ligase activity	TRIML1,AMFR,LTN1,TRAF6,UBE2L3B,ARIH1L,UBE2F,ZNRF3,MARCH4,HECW2
protein binding	STK39,pab1,INTS10,OGFR,HLX,MORN4,SYTL4,DDX39B,PTPRJ,ROS1

BIRC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC3.

TRAF2;RIPK2;RIPK4;RIPK1;RIPK3;UBA1