BIN1
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Official Full Name
bridging integrator 1 -
Overview
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a;MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system;may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin.;Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and;activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in;cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different;isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. -
Synonyms
BIN1;bridging integrator 1;AMPHL;myc box-dependent-interacting protein 1;AMPH2;amphiphysin II;SH3P9;amphiphysin-like protein;box dependant MYC interacting protein 1;box-dependent myc-interacting protein 1;MGC10367;DKFZp547F068
Recombinant Proteins
- Human
- Chicken
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
BIN1 involved in several pathways and played different roles in them. We selected most pathways BIN1 participated on our site, such as Endocytosis,Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | GIT2B,PSD,PRKCI,SMURF2,PLD2,D6WSU116E,BIN1B,DNM1B,RHOAD,IGF1R |
| Fc gamma R-mediated phagocytosis | ASAP2,NCF1,LYN,RPS6KB1,VAV1,GSN,PLD2,PIK3CD,SPHK2,MAPK1 |
Protein Function
BIN1 has several biochemical functions, for example, RNA polymerase binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIN1 itself. We selected most functions BIN1 had, and list some proteins which have the same functions with BIN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| tau protein binding | DYRK1A,S100B,AATF,FKBP4,APOE,HDAC6,SERPINB1A,SNCA,PPP2R2A |
| protein binding | TNFRSF10A,MECP2,RFWD2,URM1,PPP4R4,FANCG,CRY1A,TFPT,MSR1,SEPT3 |
| RNA polymerase binding | PPIB,WDHD1,PHRF1,NEDD4,RRN3,GSG1,TAF10,ANP32B,STOM,PKN2 |
| identical protein binding | CLDN6,DYNLRB1,CHEK2,C1S,TNF,RAD52,KCNIP2,GLUD1,MUL1,CIDEB |
Interacting Protein
BIN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIN1.
p27958-pro_0000037576;q9wmx2-pro_0000037551;FBP1;XRCC4
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References
- Xue, J; Zhou, D; et al. Novel functional interaction between Na+/H+ exchanger 1 and tyrosine phosphatase SHP-2. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 292:R2406-R2416(2007).
- Petzold, GC; Marcucci, M; et al. Rhabdomyolysis and paraneoplastic stiff-man syndrome with amphiphysin autoimmunity. ANNALS OF NEUROLOGY 55:286-290(2004).
