BCL10
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Official Full Name
B-cell CLL/lymphoma 10 -
Overview
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. -
Synonyms
BCL10;B-cell CLL/lymphoma 10;CLAP;mE10;CIPER;c-E10;CARMEN
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Mouse
- Sf9 Insect Cell
- Sf21 Insect Cell
- Wheat Germ
- E.coli
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- Non
- His
- GST
- His&SUMO
- His&Fc&Avi
Involved Pathway
BCL10 involved in several pathways and played different roles in them. We selected most pathways BCL10 participated on our site, such as NF-kappa B signaling pathway,T cell receptor signaling pathway,B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tuberculosis | MAPK1,TGFB1,IFNA16,LSP1,MRC1,CALML3,IFNA12,RAB7A,MYD88,IFNA8 |
| B Cell Receptor Signaling Pathway | LYN,LCP2A,VAV1,DUSP4,MALT1,PIK3R5,PIK3CA,DUSP6,ARPC2,GRB2 |
| T cell receptor signaling pathway | MUC1,ICOS,CD40LG,GRB2,NRAS,PAK6,CBLB,CD3E; CD3D,AKT2,PPP3R1 |
| NF-kappa B signaling pathway | PRKCQ,CXCL2,LTBR,LBP,MAP3K14,TICAM2,IL1B,TAB2,BCL2A1A,BIRC3 |
Protein Function
BCL10 has several biochemical functions, for example, NF-kappaB binding,enzyme binding,contributes_to kinase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL10 itself. We selected most functions BCL10 had, and list some proteins which have the same functions with BCL10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin binding | UBE2NB,PER2,UBAP1,C36E6.2,TRIM32,KCNS1,NEDD4,UBXN1,TOP2A,USP13 |
| transcription coactivator activity | NR2F1,PER2,MLL5,Ankar,HCFC1,TAF1,ING4,PPARGC1A,NFE2,PRMT2 |
| contributes_to kinase activator activity | MALT1 |
| kinase binding | CAB39,PFKL,CDC37,ABI2,MOB4,PER1,CTNNB1,SNAI1,PPP2R5A,PRDX3 |
| transcription factor binding | NEUROD1,FOXO1,KDM1A,IRF4,NR0B2,TAF7L,CHCHD2,KEAP1,HDAC5,TBP |
| protein kinase B binding | RARA,PDE3B,CCDC88A,PINK1,CDC37,TRAF6,ANKRD2,APPL1,BAD |
| enzyme binding | LUC7L2,UGT1A4,HMOX1,TAF10,HDHD2,CBS,RPS2,CA,RPS19BP1,FOXO4 |
| protease binding | RYR1,POLG,ELANE,DVL3,TTN,Cstb,CST3,SEMG2,ITGB3,MALT1 |
| ubiquitin protein ligase binding | DERL1,GPR19,TXNIP,UBE2G2,TRAF5,DNM1L,PRKAR2B,UCHL1,CHEK2,SQSTM1 |
Interacting Protein
BCL10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL10 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL10.
MALT1;AKT1;CARD11
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References
- Punwani, D; Wang, HP; et al. Combined Immunodeficiency Due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation. JOURNAL OF CLINICAL IMMUNOLOGY 35:135-146(2015).
- Zhao, XQ; Zhu, LL; et al. C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6 '-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-kappa B Activation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:30052-30062(2014).
