BBS5
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Official Full Name
Bardet-Biedl syndrome 5 -
Overview
This gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. Experimentation in non-human eukaryotes suggests that this gene is expressed in ciliated cells and that it is required for the formation of cilia. Alternate transcriptional splice variants have been observed but have not been fully characterized. -
Synonyms
BBS5;Bardet-Biedl syndrome 5;Bardet-Biedl syndrome 5 protein;DKFZp762I194;Bardet Biedl syndrome 5 protein
Recombinant Proteins
- Zebrafish
- Human
- Mouse
- Cynomolgus
- Chicken
- Rhesus macaque
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
Involved Pathway
BBS5 involved in several pathways and played different roles in them. We selected most pathways BBS5 participated on our site, such as Assembly of the primary cilium,BBSome-mediated cargo-targeting to cilium,Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with BBS5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Assembly of the primary cilium | ARF4,CEP76,BBS12,IFT-20,IFT46,NPHP4,TRAF3IP1,TCTEX1D1,B9D2,NEDD1 |
| Cargo trafficking to the periciliary membrane | RHOL,EXOC1,CYS1,EXOC5,CCT2,BBS7,BBS1,SETD6,UNC119.1,BBS4 |
| BBSome-mediated cargo-targeting to cilium | BBS10,CCT5,RAB3IP,MKKS,LZTFL1,TTC8,BBS12,TCP1,CCT4,BBS1 |
| Organelle biogenesis and maintenance | BBS2,C10orf2,MRPS22,NPHP4,EXOC1,NPHP1,MRPL10,EXOC8,IFT52,GABPA |
Protein Function
BBS5 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding,phosphatidylinositol-3-phosphate binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BBS5 itself. We selected most functions BBS5 had, and list some proteins which have the same functions with BBS5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | STIP1,ARHGEF3,RECQL4,NRIP2,CARD8,RAI1,PFKL,FHOD1,SETX,TREX1 |
| RNA polymerase II repressing transcription factor binding | TCF7L2,BBS1,RBBP8,BBS10,SP1,BBS2,CHD4,HDAC2,GSC,TTC8 |
| phosphatidylinositol-3-phosphate binding | TECPR1,RS1,ZFYVE28,SESTD1,WDR45L,FAM21C,WIPI2,ZFYVE19,KIF16B,JPH2 |
Interacting Protein
BBS5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BBS5 here. Most of them are supplied by our site. Hope this information will be useful for your research of BBS5.
BBS1;BBS4;147700;CRADD;BBS9;KLC3
Resources
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References
- Kagaya, A; Shimada, H; et al. Identification of a novel SEREX antigen family, ECSA, in esophageal squamous cell carcinoma. PROTEOME SCIENCE 9:-(2011).
