BBS2

  • Official Full Name

    Bardet-Biedl syndrome 2

  • Overview

    This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene forms a multiprotein BBSome complex with six other BBS proteins.

  • Synonyms

    BBS2;Bardet-Biedl syndrome 2;BBS;Bardet-Biedl syndrome 2 protein;Bardet Biedl syndrome 2;Bardet Biedl syndrome 2 protein;MGC20703

Recombinant Proteins

  • Human
  • Chicken
  • Mouse
  • Zebrafish
  • Rat
  • Wheat Germ
  • Mammalian Cell
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
BBS2-107H Recombinant Human BBS2 Protein, GST-tagged Wheat Germ Human GST
BBS2-2006C Recombinant Chicken BBS2 Mammalian Cell Chicken His
BBS2-2311M Recombinant Mouse BBS2 Protein Mammalian Cell Mouse His
BBS2-9411Z Recombinant Zebrafish BBS2 Mammalian Cell Zebrafish His
BBS2-948R Recombinant Rat BBS2 Protein Mammalian Cell Rat His
BBS2-8503HCL Recombinant Human BBS2 293 Cell Lysate HEK293 Human Non
BBS2-1585HF Recombinant Full Length Human BBS2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 721 amino acids
BBS2-606R Recombinant Rat BBS2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
BBS2-606R-B Recombinant Rat BBS2 Protein Pre-coupled Magnetic Beads HEK293 Rat
BBS2-974M Recombinant Mouse BBS2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
BBS2-974M-B Recombinant Mouse BBS2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    BBS2 involved in several pathways and played different roles in them. We selected most pathways BBS2 participated on our site, such as Assembly of the primary cilium,BBSome-mediated cargo-targeting to cilium,Cargo trafficking to the periciliary membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with BBS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Assembly of the primary cilium CLUAP1,TCP1,BBS10,CENPJ,NDE1,RPGRIP1L,TUBG1,PROL1,CCT8,CEP152
    BBSome-mediated cargo-targeting to cilium SETD6,MKKS,BBS4,CCT3,CCT5,TTC8,BBS7,BBS1,BBS9,SSTR3
    Organelle biogenesis and maintenance MRPL52,MRPS33,BBS5,IFT80,MRPS22,CYS1,ARL3,WDR35,TUFM,GABPB1
    Cargo trafficking to the periciliary membrane BBS5,CNGA2,UNC119.1,TTC8,EXOC6,CYS1,BBS7,BBS9,CCT8,RHOL

    Protein Function

    BBS2 has several biochemical functions, for example, RNA polymerase II repressing transcription factor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BBS2 itself. We selected most functions BBS2 had, and list some proteins which have the same functions with BBS2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding LGALSL,PFN2,IL7R,PI4KB,CELSR1,PPM1K,UBE2V1,HSPB11,KCNMB4,AXIN2
    RNA polymerase II repressing transcription factor binding TTC8,RBPJ,MKKS,RBBP8,TBX5A,HDAC1,BBS10,CHD4,MTA2,BBS5

    Interacting Protein

    BBS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BBS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of BBS2.

    BBS9;BBS7

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