B3GAT2
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Official Full Name
beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S) -
Overview
The product of this gene is a transmembrane protein belonging to the glucuronyltransferase family, and catalyzes the transfer of a beta-1,3 linked glucuronic acid to a terminal galactose in different glycoproteins or glycolipids containing a Gal-beta-1-4GlcNAc or Gal-beta-1-3GlcNAc residue. The encoded protein is involved in the synthesis of the human natural killer-1 (HNK-1) carbohydrate epitope, a sulfated trisaccharide implicated in cellular migration and adhesion in the nervous system. -
Synonyms
B3GAT2;beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S);GlcAT S;GlcAT-S
Recombinant Proteins
- Mouse
- Chicken
- Zebrafish
- Rat
- Human
- Mus musculus
- Mammalian Cell
- HEK293
- E.coli
- E.coli expression system
- His
- Non
- His&T7
- His&Fc&Avi
Involved Pathway
B3GAT2 involved in several pathways and played different roles in them. We selected most pathways B3GAT2 participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis,Chondroitin sulfate/dermatan sulfate metabolism,Glycosaminoglycan metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with B3GAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| A tetrasaccharide linker sequence is required for GAG synthesis | GPC6,BGNB,NCAN,CSPG4,CSPG5B,CSPG5,BGNA,Gpc2,GPC5A,GPC1A |
| Heparan sulfate/heparin (HS-GAG) metabolism | HS3ST6,B4GALT7,Gpc2,HS3ST4,MAPK1IP1L,CSPG5B,GPC1A,GPC1B,GPC5A,GLB1L |
| Chondroitin sulfate/dermatan sulfate metabolism | DSEL,CSPG5B,CHST9,CSPG4,BGNB,VCAN,CHST14,AGRN,GPC1B,BCAN |
| Other types of O-glycan biosynthesis | B3GALTLB,POMT2,B4GALT3,ST6GAL2A,B4GALT1,B3GALTL,EOGT,POGLUT1,ST3GAL3B,GLT25D2 |
| Glycosaminoglycan metabolism | CSPG5B,MAPK1IP1L,GPC1B,FMODA,HPSE,SLC35D2,SLC26A2,OMD,KERA,HS3ST6 |
| Chondroitin sulfate biosynthesis | DCN,CSPG5,CHST9,CSPG4,VCANB,UST,NCAN,BGNA,CSPG5B,BGNB |
| Metabolism | CERS5,ARSD,CYP3A5,CPT2,ACOT9.2,CYP2R1,ACOT13,PDP2,FABP9,AZIN1B |
| Metabolism of carbohydrates | HAS1,SLC25A10,DSEL,SLC5A9,SLC25A1,KIAA1199,CHP,NHLRC1,EPM2A,SLC25A11 |
Protein Function
B3GAT2 has several biochemical functions, for example, galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by B3GAT2 itself. We selected most functions B3GAT2 had, and list some proteins which have the same functions with B3GAT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | IRF2BP1,GNAT3,ZNF79,ZNF280C,MGAT5B,YBEY,MCEE,SPRTN,UQCRFS1,WDFY3 |
| galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity | B3GAT3,B3GAT1,B3GAT1A |
Interacting Protein
B3GAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B3GAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of B3GAT2.
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