B3GALNT1
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Official Full Name
beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) -
Overview
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). The encoded protein of this gene does not use N-acetylglucosamine as an acceptor sugar at all. Multiple transcript variants that are alternatively spliced in the 5 UTR have been described; they all encode the same protein. -
Synonyms
B3GALNT1;beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group);B3GALT3, UDP Gal:betaGlcNAc beta 1,3 galactosyltransferase, polypeptide 3 (Globoside blood group) , UDP GalNAc:betaGlcNAc beta 1,3 galactosaminyltransferase, polypeptide 1 (
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- HEK293
- E.coli expression system
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
B3GALNT1 involved in several pathways and played different roles in them. We selected most pathways B3GALNT1 participated on our site, such as Glycosphingolipid biosynthesis - globo series,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with B3GALNT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycosphingolipid biosynthesis - globo series | B3GALT5,FUT2,HEXB,FUT9,ST8SIA1,ST3GAL1,NAGA,GBGT1L4,HEXA,A4GALT |
| Metabolic pathways | HIBCH,CYP2P6,BAAT,FUT9,MTMR1A,PLCZ1,POLE3,MAT2A,PAICS,EXT1B |
Protein Function
B3GALNT1 has several biochemical functions, for example, UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity,galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by B3GALNT1 itself. We selected most functions B3GALNT1 had, and list some proteins which have the same functions with B3GALNT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity | B3GALT4,B3GALT2,B3GALT5,B3GALT1,B3GAT1 |
Interacting Protein
B3GALNT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with B3GALNT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of B3GALNT1.
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