AXL
-
Official Full Name
AXL receptor tyrosine kinase -
Overview
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013] -
Synonyms
AXL;AXL receptor tyrosine kinase;UFO;JTK11;tyrosine-protein kinase receptor UFO;AXL oncogene;AXL transforming sequence/gene
Recombinant Proteins
- Mouse
- Human
- Rat
- Cynomolgus
- HEK293
- E.coli
- Mammalian cells
- Sf9 Insect Cell
- Human Cell
- Wheat Germ
- Insect Cell
- Human cells
- In Vitro Cell Free System
- HEK293T
- His
- GST
- His&Fc
- Fc
- Flag
- Non
- Myc&DDK
- His&Flag
- mFc
- His&Fc&Avi
- His&SUMO
- His&T7
- Fc&Avi
- His&Avi
Involved Pathway
AXL involved in several pathways and played different roles in them. We selected most pathways AXL participated on our site, such as Signal Transduction,Signaling by VEGF,VEGFA-VEGFR2 Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AXL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by VEGF | NRP2B,DSCAMA,JUPA,SHB,NRP2A,NRP2 |
| VEGFA-VEGFR2 Pathway | JUPA,DSCAMA |
| Signal Transduction | HECW1,KIDINS220B,SDR16C5,NMBA,ARHGEF17,PCSK6,MDKB,GPR37B,GPR18,AATF |
Protein Function
AXL has several biochemical functions, for example, ATP binding,phosphatidylserine binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AXL itself. We selected most functions AXL had, and list some proteins which have the same functions with AXL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | CHUK,SFRP5,HIST1H3G,CYBA,HIST1H4J,RALGAPA1,H2AFVA,BNIP3,SOX8,SOX17 |
| ATP binding | KIF4,GRK5,ZAK,MAPK4,KCNJ8,MCCC1,CDK15,LIG3,GUK1,IRAK2 |
| virus receptor activity | SLAMF1,ITGA2,XPR1,ITGA5,HYAL2,CLDN1,IDE,SLC20A2,ITGB5,ICAM1 |
| transmembrane receptor protein tyrosine kinase activity | FLT1,DDR2,ROR1,EPHA4A,NPTN,MERTK,INSRB,ERBB3B,DDR1,NTRK3 |
| phosphatidylserine binding | SCIN,CD300A,RPE65,THBS1,MFGE8,SDPR,SYT4,CPNE6,RS1,JPH2 |
| protein tyrosine kinase activity | EPHA7,TEK,KITA,LYN,ALK,JAK3,IGF1RA,MUSK,EPHB2,SHC1 |
| protein binding | RNF4,CDK20,MPPED2,NBR1,INTS3,C18orf56,FAIM,KRT83,THBD,SH2B3 |
Interacting Protein
AXL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AXL here. Most of them are supplied by our site. Hope this information will be useful for your research of AXL.
EGFR;PLCG1;PIK3R1;GRB2;GAS6;abl-tide
Resources
Research Area
Other Cytokines & ReceptorsReceptor Tyrosine Kinases (RTKs)
Natural Killer Cell (NK Cell)
Receptor Tyrosine Kinases (RTKs) in the Akt Pathway
Related Services
Related Products
References
- Yu, Z; Li, XC; et al. 3D-QSAR modeling and molecular docking study on Mer kinase inhibitors of pyridine-substituted pyrimidines. MOLECULAR DIVERSITY 19:135-147(2015).
- Albert, R; Kristof, E; et al. Triamcinolone regulated apopto-phagocytic gene expression patterns in the clearance of dying retinal pigment epithelial cells. A key role of Mertk in the enhanced phagocytosis. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1850:435-446(2015).
