AWAT2
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Official Full Name
acyl-CoA wax alcohol acyltransferase 2 -
Overview
This gene encodes an enzyme belonging to the diacylglycerol acyltransferase family. This enzyme produces wax esters by the esterification of long chain (or wax) alcohols with acyl-CoA-derived fatty acids. It functions in lipid metabolism in the skin, mostly in undifferentiated peripheral sebocytes. This enzyme may also have acyl-CoA:retinol acyltransferase activities, where it catalyzes the synthesis of diacylglycerols and retinyl esters. -
Synonyms
AWAT2;acyl-CoA wax alcohol acyltransferase 2;DGAT2L4, diacylglycerol O acyltransferase 2 like 4;MFAT;multifunctional O acyltransferase;Acyl CoA wax alcohol acyltransferase 2;DC4;Diacylglycerol O acyltransferase 2 like 4;Diacylglycerol O acyltransferase candidate 4;Long chain alcohol O fatty acyltransferase 2;Wax synthase 2;Wax synthase;WS;multifunctional O-acyltransferase;diacylglycerol O-acyltransferase candidate 4;long-chain-alcohol O-fatty-acyltransferase 2;diacylglycerol O-acyltransferase 2-like protein 4;DGAT2L4
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| AWAT2-8555HCL | Recombinant Human AWAT2 293 Cell Lysate | HEK293 | Human | Non |
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| RFL14558HF | Recombinant Full Length Human Acyl-Coa Wax Alcohol Acyltransferase 2(Awat2) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length (1-333) |
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| RFL1534MF | Recombinant Full Length Mouse Acyl-Coa Wax Alcohol Acyltransferase 2(Awat2) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length (1-333) |
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Involved Pathway
AWAT2 involved in several pathways and played different roles in them. We selected most pathways AWAT2 participated on our site, such as Acyl chain remodeling of DAG and TAG,Arachidonic acid metabolism,Glycerophospholipid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with AWAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid biosynthesis | PHOSPHO1,MGLL,CPNE1,AGPAT1,BCHE,SLC44A5B,CPNE7,PNPLA8,ABHD4,STIL |
| Arachidonic acid metabolism | PLA2G10,CYP4A10,CYP4F3,PLA2G4D,GGT1,AKR1C6,CYP2B6,ALOX15B,CYP2C45,CYP2E1 |
| Metabolism | AZIN1,MED7,SPRB,MARCKSA,PPM1LB,OAZ1,MAPK1IP1L,SLC25A12,FAAH2,BHMT2 |
| Phospholipid metabolism | SACM1LB,PTPMT1,TPTE,PITPNB,SACM1LA,CPNE3,CPNE7,CDS1,PNPLA8,CPNE1 |
| Acyl chain remodeling of DAG and TAG | AWAT1,DGAT1B,MGLL |
| Metabolism of lipids and lipoproteins | APOF,MED29,GRHL1,ECI1,CYP2AD2,NFYBB,PPM1LA,MED20,SACM1LA,ARSK |
Protein Function
AWAT2 has several biochemical functions, for example, long-chain-alcohol O-fatty-acyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AWAT2 itself. We selected most functions AWAT2 had, and list some proteins which have the same functions with AWAT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| long-chain-alcohol O-fatty-acyltransferase activity | AWAT1 |
Interacting Protein
AWAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AWAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AWAT2.
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References
- Rodriguez, GM; Tashiro, Y; et al. Expanding ester biosynthesis in Escherichia coli. NATURE CHEMICAL BIOLOGY 10:259-+(2014).
- Guo, DY; Zhu, J; et al. Metabolic engineering of Escherichia coli for production of fatty acid short-chain esters through combination of the fatty acid and 2-keto acid pathways. METABOLIC ENGINEERING 22:69-75(2014).
