AVP
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Official Full Name
arginine vasopressin -
Overview
This gene encodes a precursor protein consisting of two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). [provided by RefSeq, Mar 2010] -
Synonyms
AVP;arginine vasopressin;VP;ADH;ARVP;AVRP;AVP-NPII;vasopressin-neurophysin 2-copeptin;neurohypophyseal;prepro-AVP-NP II;antidiuretic hormone;vasopressin-neurophysin II-copeptin;prepro-arginine-vasopressin-neurophysin II
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Zebrafish
- Mammalian Cell
- E.coli
- Mammalian cells
- HEK293
- HEK293T
- GST
- His
- His&T7
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
AVP involved in several pathways and played different roles in them. We selected most pathways AVP participated on our site, such as Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AVP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phospholipase D signaling pathway | PLCB2,SHC2,MAPK1,SYK,GRB2,LPAR5,MAP2K1,PLA2G4D,GRM8,AKT1 |
Protein Function
AVP has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity involved in apoptotic process,hormone activity,neurohypophyseal hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AVP itself. We selected most functions AVP had, and list some proteins which have the same functions with AVP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hormone activity | BMP10,GPHB5,INS1,UCN3L,CRHB,NPPC,PRL2A1,Gh,PRL7C1,PRL6A1 |
| protein kinase activity | PRKG1A,BSK146,CDK9,CSF1RA,PDK1,GRK1,EIF2AK3,TRIM28,SBK1,VRK1 |
| signal transducer activity | FPR-RS4,OMPB,TAS1R2.2,FPR3,CSPG4,PPM1A,GPR173,OLFR958,CXCR4A,MRGPRA5 |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | BIRC8,IGF1RB,SNCA,RPS6KA1,C1QL4L,TFAP2B,TNFSF14,SERPINB1A,NOL3,BIRC5 |
| neurohypophyseal hormone activity | OXT |
| neuropeptide hormone activity | VIP,NPY,QRFP,PRLH,PPY,HCRT,PYY,AGRP,CORT,UCN |
Interacting Protein
AVP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AVP here. Most of them are supplied by our site. Hope this information will be useful for your research of AVP.
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References
- Altmann, DM; et al. Host immunity to Bacillus anthracis lethal factor and other immunogens: implications for vaccine design. EXPERT REVIEW OF VACCINES 14:429-434(2015).
