Atp6v1c1
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Official Full Name
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 [ Homo sapiens ] -
Overview
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. -
Synonyms
ATP6C;ATP6D;ATP6V1C1;ATPase H+ transporting lysosomal (vacuolar proton pump) 42kD;ATPase H+ transporting lysosomal 42kD V1 subunit C isoform 1;ATPase H+ transporting lysosomal 42kDa V1 subunit C isoform 1;ATPase H+ transporting lysosomal 42kDa V1 subunit C1;ATPase H+ transporting lysosomal V1 subunit C1;FLJ20057;H(+) transporting two sector ATPase subunit C;H+ ATPase C subunit;H+ transporting ATPase chain C vacuolar;Subunit C of vacuolar proton ATPase V1 domain;V ATPase C subunit;V ATPase subunit C 1;V-ATPase subunit C 1;V-type proton ATPase subunit C 1;Vacuolar ATP synthase subunit C;Vacuolar proton pump 42 kD subunit;Vacuolar proton pump C subunit;Vacuolar proton pump subunit C 1;Vacuolar protonATPase subunit C VI domain;VATC;VATC1_HUMAN;VATPase C subunit;VATPase subunit C 1;VMA5
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Rhesus macaque
- Rat
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293T
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
Atp6v1c1 involved in several pathways and played different roles in them. We selected most pathways Atp6v1c1 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with Atp6v1c1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rheumatoid arthritis | VEGFA,H2-AA,CD86,TEK,IFNG,HLA-DRB4,GM-CSF,HLA-DQA1,HLA-DOB,HLA-DQA2 |
| Synaptic vesicle cycle | STX2,SNAP25,STX1B,SLC17A7,ATP6V0D2,ATP6V0D1,SYT1,UNC13A,ATP6V0C,ATP6V1E1 |
| Collecting duct acid secretion | ATP6V1F,ATP6V1A,ATP6V1B2,ATP6V0D1,ATP6V0E1,ATP6V1G3,CA2,ATP6V1B1,ATP6V0A1,ATP6V0A4 |
| Oxidative phosphorylation | ATP5B,COX5A,NDUFC1,COX17,ATPV0E2,ATP6V1C2,SDHDB,NDUFA13,UQCRC2B,NDUFA4 |
| Vibrio cholerae infection | ATP6V1E1,ATP6V0D1,ATP6V1G1,ACTG1,ATP6V0B,ACTB,ATP6V1H,PRKACB,ATP6AP1,ATP6V1E2 |
| Phagosome | ATP6V0C,TUBA1C,HLA-A,HLA-B,SEC61A1,TLR4BB,OLR1,MHC2DEB,ATP6V0A1A,HGS |
| Metabolic pathways | AGLA,AGL,FAXDC2,ATP5IB,HYAL6,SMS,NT5C,CERS1,BCO1L,RFK |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V0A4,CXCR2,MAPK10,PTPN11,ATP6V0C,ATP6V1B2,ATP6V1C2,NFKB1,ATP6AP1,ATP6V1G3 |
Protein Function
Atp6v1c1 has several biochemical functions, for example, hydrogen-exporting ATPase activity, phosphorylative mechanism,protein binding,proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by Atp6v1c1 itself. We selected most functions Atp6v1c1 had, and list some proteins which have the same functions with Atp6v1c1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrogen-exporting ATPase activity, phosphorylative mechanism | ATP6V1C2,ATP6V1G3,ATP6V1E2,ATP6V1E1,ATP6V1G1,ATP6V0D1 |
| protein binding | STXBP1,MYL2,Pilrb1,IWS1,TMEM11,KIF6,TICAM2,SPANXD,TARS,PDCD5 |
| transporter activity | CPNE3,SLC13A5,FABP5,RBP7,SLC4A11,SYPL2B,NUTF2,SLC13A2,SLC15A1B,LCN15 |
| proton-transporting ATPase activity, rotational mechanism | TCIRG1,ATP6V1A,ATP6V0A1A,ATP6V1E2,ATP6AP1B,ATP6V1E1B,ATP6V1AA,ATP5B,ATP6V0A2,ATP6V0A4 |
Interacting Protein
Atp6v1c1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Atp6v1c1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Atp6v1c1.
ARF6;PPARG;Arf6;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;pi3p;PPP2R1A;ATP6V1A;SMS
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