ATP6V0A1
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Official Full Name
ATPase, H+ transporting, lysosomal V0 subunit a1 -
Overview
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ATP6V0A1;ATPase, H+ transporting, lysosomal V0 subunit a1;V-type proton ATPase 116 kDa subunit a isoform 1;a1;Stv1;Vph1;ATP6N1;ATP6N1A;ATPase H+ transporting lysosomal (vacuolar proton pump) non catalytic accessory protein 1A (110/116kD);ATPase H+ transporting lysosomal non catalytic accessory protein 1 (110/116kD);ATPase H+ transporting lysosomal V0 subunit a1;Clathrin coated vesicle/synaptic vesicle proton pump 116 kDa subunit;Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit;DKFZp781J1951;H(+) transporting two sector ATPase 116 kDa accessory protein A1;V ATPase 116 kDa;V ATPase 116 kDa isoform a1;V type proton ATPase 116 kDa subunit a;V type proton ATPase 116 kDa subunit a isoform 1;V-ATPase 116 kDa isoform a1;Vacuolar adenosine triphosphatase subunit Ac116;Vacuolar proton pump subunit 1;Vacuolar proton pump, subunit 1;Vacuolar proton translocating ATPase 116 kDa subunit A;Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1;Vacuolar type H(+) ATPase 115 kDa subunit;VPP1;VPP1_HUMAN;V-ATPase 116 kDa;V-type proton ATPase 116 kDa subunit a;vacuolar-type H(+)-ATPase 115 kDa subunit;H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1;ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD);ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD)
Recombinant Proteins
- Chicken
- Rat
- Human
- Mouse
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ATP6V0A1-6289C | Recombinant Chicken ATP6V0A1 | Mammalian Cell | Chicken | His |
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| ATP6V0A1-885R | Recombinant Rat ATP6V0A1 Protein | Mammalian Cell | Rat | His |
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| ATP6V0A1-994H | Recombinant Human ATP6V0A1 protein, GST-tagged | Wheat Germ | Human | GST |
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| ATP6V0A1-8590HCL | Recombinant Human ATP6V0A1 293 Cell Lysate | HEK293 | Human | Non |
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| ATP6V0A1-1540HF | Recombinant Full Length Human ATP6V0A1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 831 amino acids |
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| ATP6V0A1-2980H | Recombinant Human ATP6V0A1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| ATP6V0A1-541R | Recombinant Rat ATP6V0A1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ATP6V0A1-541R-B | Recombinant Rat ATP6V0A1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Atp6v0a1-675M | Recombinant Mouse Atp6v0a1 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
ATP6V0A1 involved in several pathways and played different roles in them. We selected most pathways ATP6V0A1 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Synaptic vesicle cycle | SLC17A7,NAPA,ATP6V1E2,SLC18A2,VAMP2,ATP6V0A4,CPLX4,ATP6V1G1,ATP6V1H,UNC13C |
| Collecting duct acid secretion | ATP6V1E1,CA2,ATP6V1G1,ATP6V1B2,ATP6V0D2,ATP6V0A4,ATP6V1B1,ATP6V1E2,ATP6V0A2,Car2 |
| Phagosome | H2-AA,SFTPA1,TUBA1L2,FCGR4,TUBA1C,BLA,CD209A,SEC61AL2,Ctsl,CTSLA |
| Lysosome | MCOLN1,IDS,CTSBB,AP3S2,ATP6AP1,NEU1,CD68,CD63,LAPTM4A,LGMN |
| Rheumatoid arthritis | HLA-DQA2,CXCL1,HLA-DRB5,TNF,TNFSF13B,MMP1A,ATP6V1B1,ATP6V1F,ATP6V1C1,IL23 |
| Vibrio cholerae infection | TJP1,ATP6V1H,SEC61G,ATP6V1E2,ATP6V0D2,PRKACA,MUC2,TJP2,ATP6V1B2,PRKACG |
| Epithelial cell signaling in Helicobacter pylori infection | LYN,CXCR1,PLCG2,CXCL1,NOD1,MAPK8,JAM3,ATP6V0D2,MAPK13,MAPK10 |
| Oxidative phosphorylation | NDUFA4L2,ATP4B,NDUFB9,Atp5g2,MT-ND1,NDUFS1,NDUFS8B,ATP6V1AA,ATP6V1G2,COX6B2 |
| Tuberculosis | FCGR2C,FCGR2B,HLA-DRB4,RFX5,IFNA10,RFXANK,RAB5C,FCGR2A,FCGR4,RAB7A |
Protein Function
ATP6V0A1 has several biochemical functions, for example, ATPase binding,protein binding,proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0A1 itself. We selected most functions ATP6V0A1 had, and list some proteins which have the same functions with ATP6V0A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase binding | TAF9,ATP1B2,FAM119A,PEX26,ATXN3,SDF2L1,TOR1AIP2,ALDOB,FBL,ATPIF1 |
| protein binding | FANCD2,TEF,RITA1,UBE2A,NME1,CIAPIN1,GNG10,TXNRD1,RBL2,CHRM3 |
| proton-transporting ATPase activity, rotational mechanism | ATP6V1E1,ATP6V0A2B,ATP5A1,ATP6V0B,ATP6V1F,ATP6AP1B,ATP6V0CA,ATP6V0E,ATP6V0E2,TCIRG1 |
Interacting Protein
ATP6V0A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0A1.
CLIC1;SNX4;ZNF267;SEH1L;ATP6V1A;CTSD;ATP6V1B1
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References
- Tuttle, AM; Hoffman, TL; et al. Rabconnectin-3a Regulates Vesicle Endocytosis and Canonical Wnt Signaling in Zebrafish Neural Crest Migration. PLOS BIOLOGY 12:-(2014).
- Valapala, M; Wilson, C; et al. Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/beta A3/A1-crystallin via V-ATPase-MTORC1 signaling. AUTOPHAGY 10:480-496(2014).
