ATP6AP1
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Official Full Name
ATPase, H+ transporting, lysosomal accessory protein 1 -
Overview
This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. -
Synonyms
ATP6AP1;ATPase, H+ transporting, lysosomal accessory protein 1;ATP6IP1, ATP6S1, ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1;V-type proton ATPase subunit S1;16A;Ac45;CF2;ORF;VATPS1;XAP 3;XAP3;ATP6IP1;ATP6S1;ATPase H+ transporting lysosomal (vacuolar proton pump) subunit 1;ATPase H+ transporting lysosomal accessory protein 1;ATPase H+ transporting lysosomal interacting protein 1;H ATPase subunit;MGC129781;Protein XAP 3;Protein XAP3;V ATPase Ac45 subunit;V ATPase S1 accessory protein;V ATPase subunit S1;V type proton ATPase subunit S1;Vacuolar ATP synthase subunit S1;protein XAP-3;H-ATPase subunit;OTTHUMP00000032115;OTTHUMP00000196463;V-ATPase subunit S1;V-ATPase Ac45 subunit;V-ATPase S1 accessory protein;vacuolar proton pump subunit S1;ATPase, H+ transporting, lysosomal interacting pro;XAP-3
Recombinant Proteins
- Chicken
- Rat
- Human
- Mus musculus
- Bovine
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ATP6AP1-4576C | Recombinant Chicken ATP6AP1 | Mammalian Cell | Chicken | His |
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| ATP6AP1-883R | Recombinant Rat ATP6AP1 Protein | Mammalian Cell | Rat | His |
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| ATP6AP1-992H | Recombinant Human ATP6AP1 protein, GST-tagged | Wheat Germ | Human | GST |
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| ATP6AP1-8592HCL | Recombinant Human ATP6AP1 293 Cell Lysate | HEK293 | Human | Non |
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| ATP6AP1-1542HF | Recombinant Full Length Human ATP6AP1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 470 amino acids |
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| ATP6AP1-539R | Recombinant Rat ATP6AP1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ATP6AP1-539R-B | Recombinant Rat ATP6AP1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| RFL12719MF | Recombinant Full Length Mouse V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged | E.coli expression system | Mus musculus | His | Full L. Full Length of Mature Protein (33-463) |
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| RFL24115HF | Recombinant Full Length Human V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged | E.coli expression system | Human | His | Full L. Full Length of Mature Protein (42-470) |
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| RFL24987RF | Recombinant Full Length Rat V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged | E.coli expression system | Rat | His | Full L. Full Length of Mature Protein (33-463) |
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| RFL30385BF | Recombinant Full Length Bovine V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged | E.coli expression system | Bovine | His | Full L. Full Length of Mature Protein (36-468) |
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Involved Pathway
ATP6AP1 involved in several pathways and played different roles in them. We selected most pathways ATP6AP1 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6AP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis B | MAP2K4,PIK3R1,PCNA,TRP53,BIRC5,GRB2,SMAD4,PTEN,YWHAB,STAT1 |
| Vibrio cholerae infection | ATP6V1C1,MUC2,ATP6V0A1,PRKACA,ATP6V1H,ATP6V1E1,KDELR1,ATP6V0A4,ATP6V1B2,ACTG1 |
| Tuberculosis | ITGAM,CALM3,ATP6V0D2,IFNA6,CASP10,HLA-DRB5,IRAK2,IL12B,IRAK4,CD74 |
| Epithelial cell signaling in Helicobacter pylori infection | CXCR2,ATP6V1B1,PLCG2,TJP1,ATP6V1G3,PAK1,ADAM17,ATP6V0C,ATP6V1G1,ATP6V1C1 |
| Phagosome | RAC1,FAM49BA,TLR4BA,CD14,SFTPD,HLA-DRB4,CD209B,BMA2,MHC2A,THBS2 |
| Rheumatoid arthritis | Il23a; Il12b,CD86,HLA-DQA2,ATP6V1B1,IL-8,IL1A,FLT1,H2-AB1,IL1B,CCL2 |
| Metabolic pathways | HSD17B6,DGKD,HYAL2,IDUA,MDH2,HYAL6,AGXT2L2,UGP2,UQCRC2,DSE |
| Oxidative phosphorylation | ATP6V0E1,ATP5A1,NDUFB1,ATP6V1E1,ATP6V1B2,NDUFS5,ATP6V1A,ATP5H,ATP5G3B,NDUFA5 |
| Lysosome | CD68,LGMN,GGA3,CTSA,HEXB,AP3S1,GUSB,IDS,PSAPL1,NAPSA |
Protein Function
ATP6AP1 has several biochemical functions, for example, ATP binding,Rab GTPase binding,proton-transporting ATP synthase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6AP1 itself. We selected most functions ATP6AP1 had, and list some proteins which have the same functions with ATP6AP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| Rab GTPase binding | FER,MICAL1,AP1G1,CHML,MLPH,PDE6D,SYTL1,CFAP45,ANKFY1,GOLGA5 |
| proton-transporting ATP synthase activity, rotational mechanism | ATP5B,ATP5C1,ATP6AP1B,ATP6V0C,ATP5A1,ATP5O,ATP5E |
| transporter activity | HIAT1,AQP12B,SLC23A2,SLC2A11B,SLC2A8,ABCC1,ABCB1,HIATL2,SLCO1F4,AP4M1 |
| proton-transporting ATPase activity, rotational mechanism | ATP6V1AA,ATP6AP1B,TCIRG1,ATP6V1E1,ATPV0E2,ATP5A1,ATP5B,ATP6V0E1,ATP6V0A1A,ATP6V0A1 |
| ATP binding | DAPK3,TEX14,CAMK1DB,MYO7AA,DDX56,PIK3C2G,PI4K2B,CAMK1DA,UBE2NB,ABCC3 |
Interacting Protein
ATP6AP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6AP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6AP1.
NR1I2;ANG;ERBB2;HBA1;Kcnk1;ATP6AP2;cona_canen;Bmpr1a;RAB7A;K3;DBN1;Chmp4b;MYEF2;Spast;Tmed2;GOLT1B
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