ATP6AP1

  • Official Full Name

    ATPase, H+ transporting, lysosomal accessory protein 1

  • Overview

    This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules.

  • Synonyms

    ATP6AP1;ATPase, H+ transporting, lysosomal accessory protein 1;ATP6IP1, ATP6S1, ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1;V-type proton ATPase subunit S1;16A;Ac45;CF2;ORF;VATPS1;XAP 3;XAP3;ATP6IP1;ATP6S1;ATPase H+ transporting lysosomal (vacuolar proton pump) subunit 1;ATPase H+ transporting lysosomal accessory protein 1;ATPase H+ transporting lysosomal interacting protein 1;H ATPase subunit;MGC129781;Protein XAP 3;Protein XAP3;V ATPase Ac45 subunit;V ATPase S1 accessory protein;V ATPase subunit S1;V type proton ATPase subunit S1;Vacuolar ATP synthase subunit S1;protein XAP-3;H-ATPase subunit;OTTHUMP00000032115;OTTHUMP00000196463;V-ATPase subunit S1;V-ATPase Ac45 subunit;V-ATPase S1 accessory protein;vacuolar proton pump subunit S1;ATPase, H+ transporting, lysosomal interacting pro;XAP-3

Recombinant Proteins

  • Chicken
  • Rat
  • Human
  • Mus musculus
  • Bovine
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • E.coli
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ATP6AP1-4576C Recombinant Chicken ATP6AP1 Mammalian Cells Chicken His
ATP6AP1-883R Recombinant Rat ATP6AP1 Protein Mammalian Cells Rat His
ATP6AP1-992H Recombinant Human ATP6AP1 protein, GST-tagged Wheat Germ Human GST
ATP6AP1-8592HCL Recombinant Human ATP6AP1 293 Cell Lysate HEK293 Human Non
ATP6AP1-1542HF Recombinant Full Length Human ATP6AP1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 470 amino acids
ATP6AP1-539R Recombinant Rat ATP6AP1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
ATP6AP1-539R-B Recombinant Rat ATP6AP1 Protein Pre-coupled Magnetic Beads HEK293 Rat
RFL12719MF Recombinant Full Length Mouse V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length of Mature Protein (33-463)
RFL24115HF Recombinant Full Length Human V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged E.coli Human His Full L. Full Length of Mature Protein (42-470)
RFL24987RF Recombinant Full Length Rat V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged E.coli Rat His Full L. Full Length of Mature Protein (33-463)
RFL30385BF Recombinant Full Length Bovine V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged E.coli Bovine His Full L. Full Length of Mature Protein (36-468)

    Involved Pathway

    ATP6AP1 involved in several pathways and played different roles in them. We selected most pathways ATP6AP1 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6AP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Epithelial cell signaling in Helicobacter pylori infection ATP6V1B1,PLCG2,ATP6V1E1,MAP2K4,GIT1,ATP6V0E1,ATP6V1E2,ATP6V1G3,ATP6V0A1,IL-8
    Tuberculosis ITGAX,TGFB2,IRAK4,HLA-DMB,ATP6V0A2,IL12B,MAPK9,SPHK1,IFNA8,NFYC
    Lysosome CTSJ,GGA2,CTSBA,CTSG,GM2A,MAN2B1,AGA,AP4E1,LGMN,CTSL1B
    Vibrio cholerae infection ATP6V0D1,ATP6V0A1,TJP2,ATP6V1E2,ATP6V1F,PLCG1,ACTB,ATP6V1B2,PLCG2,ATP6V1C1
    Hepatitis B IL-8,IFNA2,OSTN,RELA,APAF1,TLR4,PIK3R3,CREB5,IFNB1,CCND1
    Phagosome THBS4,TUBA1C,MHC2DEB,ITGB1,ATP6V1C1,BLB2,TUBA3D,TUBB2,C1RA,HLA-DOA
    Oxidative phosphorylation NDUFB11,COX7A2L,ATP6V1G2,ATP12A,NDUFV3,MT-ND4,ATP6V1H,ATP5J,ATP5D,COX6B2
    Rheumatoid arthritis IL17A,ATP6V1B1,CD86,CCL2,FLT1,HLA-DRB1,ATP6V1F,IL1B,HLA-DQA2,ATP6V0A4
    Metabolic pathways GSTZ1,GGT7,GCNT2,UGT1A7,CYP4A14,PIGN,GALNT6,PLA2G4F,HEXB,ALOX5

    Protein Function

    ATP6AP1 has several biochemical functions, for example, ATP binding,Rab GTPase binding,proton-transporting ATP synthase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6AP1 itself. We selected most functions ATP6AP1 had, and list some proteins which have the same functions with ATP6AP1. You can find most of the proteins on our site.

    Function Related Protein
    transporter activity RASSF9,FLR,SLC13A2,MIP,CPNE1,APODB,CRABP2,FABP5,PBSN,SEC14L2
    proton-transporting ATPase activity, rotational mechanism ATP6V0A1A,ATP6V0A4,ATP6V0CB,ATP6V1A,ATP6V1H,ATP6V0C,ATP6AP1B,ATP6V0E,ATP6V1B2,TCIRG1
    ATP binding EPB42,MYO10,MAST2,PEO1,CDK13,DNAH14,PIM2,YSK4,TTLL4,FER
    Rab GTPase binding RABGAP1,RIN3,GOLGA5,RABGGTA,RABGEF1,PIFO,STXBP5L,CHML,SYTL3,STX4A
    proton-transporting ATP synthase activity, rotational mechanism ATP6AP1B,ATP5C1,ATP6V0C,ATP5E,ATP5O,ATP5A1,ATP5B

    Interacting Protein

    ATP6AP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6AP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6AP1.

    NR1I2;ANG;ERBB2;HBA1;Kcnk1;ATP6AP2;cona_canen;Bmpr1a;RAB7A;K3;DBN1;Chmp4b;MYEF2;Spast;Tmed2;GOLT1B

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