ATP5C1
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Official Full Name
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 -
Overview
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the gamma subunit of the catalytic core. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene also has a pseudogene on chromosome 14. -
Synonyms
ATP5C1;ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1;ATP5C, ATP5CL1;ATP synthase subunit gamma, mitochondrial;ATP synthase gamma chain, mitochondrial;ATP synthase, H+ transporting, mitochondrial F1 complex, gamma subunit;ATP5C 1;ATP5C;ATP5CL1;F ATPase gamma subunit;Mitochondrial ATP synthase, gamma subunit 1;F-ATPase gamma subunit
Recombinant Proteins
- Human
- Zebrafish
- Cynomolgus
- Rat
- Bovine
- Chicken
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Myc
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ATP5C1-10016H | Recombinant Human ATP5C1, GST-tagged | E.coli | Human | GST | 1-298a.a. | |
| ATP5C1-10396Z | Recombinant Zebrafish ATP5C1 | Mammalian Cell | Zebrafish | His |
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| ATP5C1-132H | Recombinant Human ATP5C1Protein, His-tagged | E.coli | Human | His |
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| ATP5C1-133H | Recombinant Human ATP5C1 Protein, His-tagged | E.coli | Human | His |
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| ATP5C1-322C | Recombinant Cynomolgus ATP5C1 Protein, His-tagged | Mammalian Cell | Cynomolgus | His |
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| Atp5c1-3722R | Recombinant Rat Atp5c1, His-tagged | E.Coli or Yeast | Rat | His | 273 |
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| ATP5C1-3723B | Recombinant Bovine ATP5C1, His-tagged | E.Coli or Yeast | Bovine | His | 298 |
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| ATP5C1-5361C | Recombinant Chicken ATP5C1 | Mammalian Cell | Chicken | His |
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| ATP5C1-7626H | Recombinant Human ATP5C1, His-tagged | E.coli | Human | Non | 26-298aa |
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| ATP5C1-978H | Recombinant Human ATP5C1 protein, GST-tagged | Wheat Germ | Human | GST |
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| ATP5C1-8603HCL | Recombinant Human ATP5C1 293 Cell Lysate | HEK293 | Human | Non |
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| ATP5C1-8604HCL | Recombinant Human ATP5C1 293 Cell Lysate | HEK293 | Human | Non |
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| ATP5C1-1175H | Recombinant Human ATP5C1 protein, His&Myc-tagged | E.coli | Human | His&Myc | 26-298aa |
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| ATP5C1-1388HF | Recombinant Full Length Human ATP5C1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 298 amino acids |
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| ATP5C1-72C | Recombinant Cynomolgus Monkey ATP5C1 Protein, His (Fc)-Avi-tagged | HEK293 | Cynomolgus | His&Fc&Avi |
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| ATP5C1-72C-B | Recombinant Cynomolgus Monkey ATP5C1 Protein Pre-coupled Magnetic Beads | HEK293 | Cynomolgus |
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Involved Pathway
ATP5C1 involved in several pathways and played different roles in them. We selected most pathways ATP5C1 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP5C1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Parkinsons disease | NDUFS3,NDUFA11,VDAC3,UBA1,NDUFB5,UBE1Y1,NDUFA4,ATP5O,NDUFA9,MT-ND4 |
| Huntingtons disease | POLR2L,PLCB2,HAP1,DNALC4,TFAM,SLC25A6,SLC25A5,NDUFC2-KCTD14,ATP5B,COX6A1 |
| Oxidative phosphorylation | NDUFA3,NDUFB9,ATP6V1E2,NDUFA1,NDUFA12,COX7B2,NDUFA4,NDUFS4,COX5B2,Atp5g2 |
| Alzheimers disease | NDUFA8,ATP5H,UQCRC1,MT-ATP6,Casp3,GRIN1,CAPN1,NDUFA1,CASP12,ATP2A1 |
| Metabolic pathways | GMPS,SC5D,PHOSPHO1,ALDH9A1B,PNPO,HAO1,ADI1,COX15,UCK1,PLA2G10 |
Protein Function
ATP5C1 has several biochemical functions, for example, contributes_to ATPase activity,poly(A) RNA binding,proton-transporting ATP synthase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP5C1 itself. We selected most functions ATP5C1 had, and list some proteins which have the same functions with ATP5C1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ATPase activity | ATP5B,ATP5J2,ATP5H,RUVBL2,ATP5L,ATP5E,MSH2,MSH6,ATP5I,ATP1B1 |
| proton-transporting ATP synthase activity, rotational mechanism | ATP5A1,ATP5E,ATP5O,ATP6AP1,ATP5B,ATP6V0C,ATP6AP1B |
| proton-transporting ATPase activity, rotational mechanism | ATP6AP1B,ATP6V0B,TCIRG1,ATP6V1F,ATP5A1,ATP6V1H,ATP6V1B2,ATP6V0CB,ATP6AP1,ATP6V1E2 |
| poly(A) RNA binding | LSM4,TNS1,IFI16,LTA4H,PRR3,CLTC,SYNE1,NOA1,FAM120B,CANX |
| transmembrane transporter activity | SLC22A17,ATP5A1,SLC22A13,SLCO1D1,ATP5I,AQP1,RALBP1,SLC2A1A,SLC22A20,SLC2A11B |
Interacting Protein
ATP5C1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP5C1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP5C1.
MYC;VCAM1;P;ATF2;ATP5F1;CA12;NDUFB3;EGFR;SERPINA1;ITIH2;PTN;CCND3;ELOF1
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References
- Ding, BQ; Xi, Y; et al. Gene Expression Profiles of Entorhinal Cortex in Alzheimer's Disease. AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS 29:526-532(2014).
- MacLeod, G; Varmuza, S; et al. Tandem Affinity Purification in Transgenic Mouse Embryonic Stem Cells Identifies DDOST as a Novel PPP1CC2 Interacting Protein. BIOCHEMISTRY 51:9678-9688(2012).
