ATP5A1
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Official Full Name
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle -
Overview
This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the same protein have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. -
Synonyms
ATP5A1;ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle;ATP synthase subunit alpha, mitochondrial;ATP5A;hATP1;OMR;ORM;mitochondrial;ATP synthase alpha chain, mitochondrial;ATP synthase subunit alpha;ATP synthase subunit alpha mitochondrial;ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 1, cardiac muscle;ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit, isoform 2, non-cardiac muscle-like 2;ATP sythase (F1 ATPase) alpha subunit;ATP5AL2;ATPA_HUMAN;ATPM;Mitochondrial ATP synthetase oligomycin resistant;MOM2;MS502;OTTHUMP00000163475;ATP sythase (F1-ATPase) alpha subunit;mitochondrial ATP synthetase, oligomycin-resistant
Recombinant Proteins
- Human
- Mouse
- Pig
- Rat
- Rhesus macaque
- Zebrafish
- Chicken
- E.coli
- HEK293
- E.Coli/Yeast
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- His
- DDK
- Myc
- GST
- Non
- Avi
- Fc
- Flag
Involved Pathway
ATP5A1 involved in several pathways and played different roles in them. We selected most pathways ATP5A1 participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP5A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | ATP5G3B,ATP5G1,mt-Atp8,ATP6V1B1,ATP6V1H,NDUFA10,SDHB,ATP6V0A2,NDUFB1,NDUFA3 |
| Alzheimers disease | IL1B2,NDUFS7,EIF2AK3,COX6B1,GAPDH,CALM1,ATP5E,PPP3CA,GRIN2C,CALML3 |
| Metabolic pathways | IPMKB,PLA2G12A,SMPD2A,PAFAH2,NDUFB11,CEPT1,PNPLA2,NADSYN1,ATP5O,HK3 |
| Parkinsons disease | CYCS,NDUFA10,NDUFB11,NDUFS4,UQCRH,ATP5F1,SLC6A3,NDUFA12,PPIF,NDUFS8 |
| Huntingtons disease | COX4I1,BDNF,COX6A2,DNAHC8,NDUFB8,DNAH5,NDUFB1,DCTN4,NDUFA7,COX6B2 |
Protein Function
ATP5A1 has several biochemical functions, for example, ATP binding,contributes_to ATPase activity,MHC class I protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP5A1 itself. We selected most functions ATP5A1 had, and list some proteins which have the same functions with ATP5A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to ATPase activity | ABCG8,SFRP5,ATP1A2,ATP5E,ATP1B1,ABCA7,ATP5O,MSH2,ATP5J2,ATP6V1H |
| transmembrane transporter activity | CX43,ATP5O,SLC22A13,ATP5J2,ATP5I,SLC22A7A,SLCO1D1,SLC22A17,ATP5E,SLC2A3A |
| poly(A) RNA binding | RPL5A,UTP23,MRPS21,CHERP,FAM46A,IFIT2,RPL3,RBM3,ZFP768,ANXA2 |
| protein binding | TJP1,C16orf53,MAP3K5,Icosl,MED25,VAV3,POLD1,RBP5,MAB21L2,TBKBP1 |
| proton-transporting ATPase activity, rotational mechanism | ATP6V1AA,ATP6V0A4,ATP6V0A2,ATP6V0A2B,TCIRG1,ATP6V0A1,ATP5D,ATP6V0E1,ATP6V0C,ATP6V1B2 |
| proton-transporting ATP synthase activity, rotational mechanism | ATP5B,ATP6AP1B,ATP5E,ATP6V0C,ATP5C1,ATP5O,ATP6AP1 |
| ATP binding | PFKMA,AKT1,MAPK12B,UBE2I,UBA5,CAMK2D1,TRMU,SMOK2B,UBA2,SNRKB |
| MHC class I protein binding | ATP5B,TAPBP,Pilrb1,PILRB,CD244,HLA-E,CD8B,LILRB2,TUBB,LILRB1 |
Interacting Protein
ATP5A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP5A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP5A1.
YWHAZ;VCAM1;SIRT3;CSNK2A1;TNFRSF1A;TNFRSF1B;ATP5F1;YWHAB;ACTB;YWHAG;BLOC1S1
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References
- Lucas, EK; Dougherty, SE; et al. PGC-1 alpha Provides a Transcriptional Framework for Synchronous Neurotransmitter Release from Parvalbumin-Positive Interneurons. JOURNAL OF NEUROSCIENCE 34:14375-14387(2014).
- Ogura, M; Yamaki, J; et al. Phosphorylation of flotillin-1 by mitochondrial c-Src is required to prevent the production of reactive oxygen species. FEBS LETTERS 588:2837-2843(2014).
