ATP2A1
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Official Full Name
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -
Overview
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in two transcript variants encoding different isoforms. -
Synonyms
ATP2A1;ATPase, Ca++ transporting, cardiac muscle, fast twitch 1;ATP2A;sarcoplasmic/endoplasmic reticulum calcium ATPase 1;SERCA1;calcium pump 1;SR Ca(2+)-ATPase 1;endoplasmic reticulum class 1/2 Ca(2+) ATPase;calcium-transporting ATPase sarcoplasm
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- Mammalian cells
- HEK293
- HEK293T
- His
- GST
- Flag
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ATP2A1 involved in several pathways and played different roles in them. We selected most pathways ATP2A1 participated on our site, such as Calcium signaling pathway,cGMP-PKG signaling pathway,Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | FXYD2,SRF,CREB3L1,PRKCE,RAF1,MAPK1,PPP3R1,PRKG2,GTF2I,MYH7 |
| Pancreatic secretion | CPA2,CLCA1,CPB1,LOC780933,RYR2,PLCB1,RAC1,TPCN2,RAP1B,CA2 |
| Alzheimers disease | NDUFB8,EIF2AK3,SDHC,COX7B,NDUFA8,NDUFA5,COX6C,BACE1,COX6A2,ITPR3 |
| Calcium signaling pathway | CACNA1DA,P2RX1,HTR7,PRKACG,TACR3,PLCB1,PRKACA,PDE1A,PTK2BB,ORAI3 |
Protein Function
ATP2A1 has several biochemical functions, for example, ATP binding,calcium ion binding,calcium-transporting ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2A1 itself. We selected most functions ATP2A1 had, and list some proteins which have the same functions with ATP2A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-transporting ATPase activity | ATP2B1B,ATP2B3B,ATP2A3,ATP2B1,ATP2A2A,ATP2C2,ATP2B1A,ATP2B3A,ATP2A2B,ATP2B2 |
| calcium ion binding | PLCH2,PCDHGA1,TNNC1B,CALM2,PCDH2G28,CALU,CDHR1,DSG1A,ACTN2,PCDHGB4 |
| ATP binding | ACTR1A,MYO6B,NLRC3,CCT8,P2RY2,MAPK8A,SYN3,MAT2AA,NAV2,SMC2 |
| protein binding | ATP4B,C17orf59,INTS9,YAF2,PYY,ANKRD1,RXFP1,TFRC,AKAP12,FAM167A |
| protein homodimerization activity | CCDC88A,HSPB6,HELT,VPS24,CDSN,KIT,LGALS6,HM13,DMRTA2,ENPP1 |
Interacting Protein
ATP2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2A1.
TNFRSF1B;TULP3;RNF167;APPL1;15-deoxy-delta(12,14
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References
- Asahi, M; Kurzydlowski, K; et al. Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs). JOURNAL OF BIOLOGICAL CHEMISTRY 277:26725-26728(2002).
- Ji, Y; Loukianov, E; et al. SERCA1a can functionally substitute for SERCA2a in the heart. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 276:H89-H97(1999).
