ATF6B
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Official Full Name
activating transcription factor 6 beta -
Overview
The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ATF6B;activating transcription factor 6 beta;cAMP responsive element binding protein like 1 , CREBL1;cyclic AMP-dependent transcription factor ATF-6 beta;G13;G13 protein;ATF 6 beta;ATF6-beta;ATF6B_HUMAN;ATF6beta;cAMP response element binding protein related protein;cAMP response element-binding protein-related protein;cAMP responsive element binding protein like 1;cAMP-dependent transcription factor ATF-6 beta;cAMP-responsive element-binding protein-like 1;CREB L1;Creb related protein;CREB RP;Creb-rp;CREBL 1;CREBL1;Crebrp;Cyclic AMP dependent transcription factor ATF 6 beta;Cyclic AMP dependent transcription factor ATF6 beta;FLJ10066;OTTHUMP00000029432;OTTHUMP00000029433;Processed cyclic AMP-dependent transcription factor ATF-6 beta;Protein G13;Creb-related protein;cAMP responsive element binding protein-like 1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Mus musculus
- E.coli
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- GST
- His
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ATF6B-9965H | Recombinant Human ATF6B, GST-tagged | E.coli | Human | GST | 1-318a.a. | |
| ATF6B-2070M | Recombinant Mouse ATF6B Protein | Mammalian Cells | Mouse | His |
|
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| ATF6B-26100TH | Recombinant Human ATF6B Protein, GST-tagged | Wheat Germ | Human | GST | 1 a.a. - 318 a.a. |
|
| ATF6B-26189TH | Recombinant Human ATF6B | Wheat Germ | Human | Non | 87 amino acids |
|
| ATF6B-4821Z | Recombinant Zebrafish ATF6B | Mammalian Cells | Zebrafish | His |
|
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| ATF6B-1520HF | Recombinant Full Length Human ATF6B Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 318 amino acids |
|
| ATF6B-816M | Recombinant Mouse ATF6B Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
|
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| ATF6B-816M-B | Recombinant Mouse ATF6B Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| RFL-9388MF | Recombinant Full Length Mouse Cyclic Amp-Dependent Transcription Factor Atf-6 Beta(Atf6B) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length of Mature Protein (2-699) |
|
Involved Pathway
ATF6B involved in several pathways and played different roles in them. We selected most pathways ATF6B participated on our site, such as Adrenergic signaling in cardiomyocytes,Alcoholism,Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATF6B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| G1 to S cell cycle control | CDKN1C,TFDP1B,MYT1,E2F6 |
| Dopaminergic synapse | AKT1,COMT,GNAI1,KIF5C,PRKACG,PPP2R1B,CREB3L3,CREB3L4,CREB3L2,CLOCK |
| Estrogen signaling pathway | MMP2,KRAS,AKT1,GRB2,KCNJ9,HRAS,ITPR1,ITPR3,GNAI2,HSPA1B |
| Adrenergic signaling in cardiomyocytes | ATP1B1B,CACNA1C,RYR2,CACNB1,CAMK2D2,GNA11A,GNA15.1,ATP1A2A,MYH7,AGTR1A |
| Alcoholism | GM14482,HDAC5,HIST1H2AH,GRIN3A,HIST2H2BB,MAPK3,H2AFJ,HIST1H4B,GNAO1,GNAI3 |
| Aldosterone synthesis and secretion | NR4A1,CREB3L3,ATF2,CYP21A1,NETO2,ATF4,Adcy4,PRKCG,CREB3L4,CALML5 |
| Cocaine addiction | CREB3,SLC6A3,GRIN2B,SLC18A1,PRKACG,FOSB,MAOB,DRD1A,GRIA2,SLC18A2 |
Protein Function
ATF6B has several biochemical functions, for example, cAMP response element binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATF6B itself. We selected most functions ATF6B had, and list some proteins which have the same functions with ATF6B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SPRR2E,LGI1,BBS13,HDGF2,KIAA1530,UBE4A,AIG1,EPHB6,MIIP,IKZF2 |
| sequence-specific DNA binding | PRDM16,TCF7L1A,SALL2,RORA,UNCX,RAD21A,NR2F6B,ELF2,DMBX1B,HOXA9B |
| cAMP response element binding | CREB3L3,CREB3L1,HMGA2,ATF6,CREB3L4,E4F1,JUN,CREB1,ATF2,CREB3L3L |
| transcription regulatory region DNA binding | GRHL1,FOS,HNRNPL,HINFP,LEF1,SOX5,SNCA,TRP63,TBX16,GFI1 |
| transcription factor activity, sequence-specific DNA binding | SMAD9,NR6A1B,FOXC2,AHRRB,HOXD3,ZSCAN20,FUBP1,SRF,ZKSCAN14,GPBP1L1 |
Interacting Protein
ATF6B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATF6B here. Most of them are supplied by our site. Hope this information will be useful for your research of ATF6B.
p27958-pro_0000037575;CDK6;ysuB;proP16;proP17
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References
- Maganti, A; Evans-Molina, C; et al. From immunobiology to beta-cell biology The changing perspective on type 1 diabetes. ISLETS 6:-(2014).
- Osborne, B; Yao, TW; et al. A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1844:1248-1259(2014).
