ASXL2
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Official Full Name
additional sex combs like 2 (Drosophila) -
Overview
ASXL2 is a human homolog of the Drosophila asx gene. Drosophila asx is an enhancer of trithorax (see MIM 159555) and;polycomb (see MIM 610231) (ETP) gene that encodes a chromatin protein with dual functions in transcriptional;activation and silencing (Katoh and Katoh, 2003 (PubMed 12888926)). -
Synonyms
ASXL2;additional sex combs like 2 (Drosophila);putative Polycomb group protein ASXL2;ASXH2;FLJ10898;KIAA1685;Additional sex combs like 2;Additional sex combs like protein 2;Additional sex combs-like protein 2;ASXL 2;ASXL2_HUMAN;DKFZp686C1968;Polycomb group protein ASXH2
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ASXL2-2770C | Recombinant Chicken ASXL2 | Mammalian Cell | Chicken | His |
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| ASXL2-142HCL | Recombinant Human ASXL2 cell lysate | Human | Non |
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Involved Pathway
ASXL2 involved in several pathways and played different roles in them. We selected most pathways ASXL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ASXL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
ASXL2 has several biochemical functions, for example, DNA binding,metal ion binding,peroxisome proliferator activated receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASXL2 itself. We selected most functions ASXL2 had, and list some proteins which have the same functions with ASXL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peroxisome proliferator activated receptor binding | EP300,PPARGC1A,ASXL1,IKBKG,HMGA1,MED1,NR0B2,PRMT2,NFATC4,HMGA1-RS1 |
| DNA binding | HDGFRP2,KDM5A,GATA5,HIST1H2AG,NFE2L2A,ZNF776,CENPC1,MYCLB,ZFP821,HOXA4 |
| metal ion binding | TDO2,ZNF608,POLD1,SMPD4,TGM2,BTR12,ZEB2A,SH3RF3,ILKAP,ASGR1 |
Interacting Protein
ASXL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASXL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASXL2.
SMNDC1;BAP1;Bap1;TRAF6;PRPF40A;fusA
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References
- Lai, HL; Wang, QT; et al. Additional Sex Combs-Like 2 Is Required for Polycomb Repressive Complex 2 Binding at Select Targets. PLOS ONE 8:-(2013).
- Fisher, CL; Lee, I; et al. Additional sex combs-like 1 belongs to the enhancer of trithorax and polycomb group and genetically interacts with Cbx2 in mice. DEVELOPMENTAL BIOLOGY 337:9-15(2010).
