ASB2

  • Official Full Name

    ankyrin repeat and SOCS box containing 2

  • Overview

    This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

  • Synonyms

    ASB2;ankyrin repeat and SOCS box containing 2;ankyrin repeat and SOCS box protein 2;ASB 2;ankyrin repeat and SOCS box-containing protein 2a;ASB-2;MGC40044

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ASB2-2014M Recombinant Mouse ASB2 Protein Mammalian Cell Mouse His
ASB2-817R Recombinant Rat ASB2 Protein Mammalian Cell Rat His
ASB2-891H Recombinant Human ASB2 protein, GST-tagged Wheat Germ Human GST
ASB2-40HCL Recombinant Human ASB2 lysate HEK293 Human Non
ASB2-1204HF Recombinant Full Length Human ASB2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 587 amino acids
ASB2-473R Recombinant Rat ASB2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ASB2-473R-B Recombinant Rat ASB2 Protein Pre-coupled Magnetic Beads HEK293 Rat
ASB2-777M Recombinant Mouse ASB2 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ASB2-777M-B Recombinant Mouse ASB2 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ASB2 involved in several pathways and played different roles in them. We selected most pathways ASB2 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class I MHC mediated antigen processing &amp RNF220,VPRBP,ASB8,FBXO27,PJA1,CTSL2,CYBA,ATG7,SH3RF1,ARIH2
    Immune System IFIT10,EGR1,DCTN3,TRIM38,KLRB1F,MYO9B,C1rb,PAG1,MB21D1,SH2D1B
    Adaptive Immune System BLK,CREB1B,ACTR1A,RNF111,DTX3L,RAET1E,AMICA1,IGLC2,ITPR2,BLMH
    Antigen processing: Ubiquitination &amp RNF6,TRIM63,TRIM11,RNF25,ASB3,TRAF7,MKRN1,SPSB2,RNF123,VPRBP
    presentation ASB6,GAN,TPP2,FBXO3,KLHL21,RNF25,RNF6,KLHL20,FBXO27,ASB8
    Proteasome degradation UBE2L6,UBE2J2,RNF111,PJA1,RNF6,LRSAM1,TRIM63,RNF25,GAN,UBE2F

    Protein Function

    ASB2 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASB2 itself. We selected most functions ASB2 had, and list some proteins which have the same functions with ASB2. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SUDS3,KCNRG,RGS16,POLG2,DMPK,KSR1,TP53BP1,KRTAP12-1,MIEN1,TNNI1

    Interacting Protein

    ASB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASB2.

    HSP90AB1;CUL5;RNF7;SMAD9;ESR2

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