ASAP3
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Official Full Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 -
Overview
This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. -
Synonyms
ASAP3;ArfGAP with SH3 domain, ankyrin repeat and PH domain 3;DDEFL1, development and differentiation enhancing factor like 1;arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3;centaurin;beta 6;CENTB6;FLJ20199;UPLC1;centaurin,
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cell
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- HEK293
- GST
- His
- Non
- Flag
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ASAP3-9912H | Recombinant Human ASAP3, GST-tagged | E.coli | Human | GST | 558-903a.a. | |
| ASAP3-2438H | Recombinant Human ASAP3 Protein, GST-tagged | Wheat Germ | Human | GST |
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| ASAP3-3702Z | Recombinant Zebrafish ASAP3 | Mammalian Cell | Zebrafish | His |
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| ASAP3-450HCL | Recombinant Human ASAP3 cell lysate | Human | Non |
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| ASAP3-1261HFL | Recombinant Full Length Human ASAP3 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| Asap3-1733M | Recombinant Mouse Asap3 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| ASAP3-2446HF | Recombinant Full Length Human ASAP3 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 903 amino acids |
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| ASAP3-2821H | Recombinant Human ASAP3 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| ASAP3-385H | Recombinant Human ASAP3 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| ASAP3-385H-B | Recombinant Human ASAP3 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
ASAP3 involved in several pathways and played different roles in them. We selected most pathways ASAP3 participated on our site, such as Endocytosis,Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASAP3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | VPS35,GIT2,ARPC5A,RHOAB,EGFRA,ARPC2,EHD1,RNF41,AP2M1B,MHC1UXA2 |
| Fc gamma R-mediated phagocytosis | FCGR3A,VASP,PLA2G4F,PPAP2B,VAV1,GSN,PIP5K1A,PLD1,cgr2b,WASF3 |
Protein Function
ASAP3 has several biochemical functions, for example, GTPase activator activity,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASAP3 itself. We selected most functions ASAP3 had, and list some proteins which have the same functions with ASAP3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LHX4,ATP4B,STK25,GEMIN7,SESN2,BMP10,RBM4,SHKBP1,VIPR1,SLX4IP |
| metal ion binding | ZFP639,TRIM35-28,FBP1,ZNF454,NUBP1,KLK4,BRD1B,CYP2J5,CYP1C1,PVALB5 |
| GTPase activator activity | RIC8B,RASA3,RP2,RAP1GDS1,SIPA1L2,ARHGAP10,HTR2B,TBC1D13,TBC1D1,RANGAP1 |
Interacting Protein
ASAP3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASAP3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASAP3.
REL;UBE3A;TFCP2;PDZD3;CRK
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References
- Luo, Y; Kong, F; et al. Loss of ASAP3 destabilizes cytoskeletal protein ACTG1 to suppress cancer cell migration. MOLECULAR MEDICINE REPORTS 9:387-394(2014).
