ASAP1
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Official Full Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -
Overview
This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ASAP1;ArfGAP with SH3 domain, ankyrin repeat and PH domain 1;DDEF1, development and differentiation enhancing factor 1;arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1;centaurin;beta 4;CENTB4;KIAA1249;PAP;ZG14P;DEF-1;cent
Recombinant Proteins
- Mouse
- Bovine
- Rat
- Human
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ASAP1-2002M | Recombinant Mouse ASAP1 Protein | Mammalian Cell | Mouse | His |
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| ASAP1-3617B | Recombinant Bovine ASAP1, His-tagged | E.Coli or Yeast | Bovine | His | 1129 |
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| ASAP1-816R | Recombinant Rat ASAP1 Protein | Mammalian Cell | Rat | His |
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| ASAP1-881H | Recombinant Human ASAP1 protein, GST-tagged | Wheat Germ | Human | GST |
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| ASAP1-8668HCL | Recombinant Human ASAP1 293 Cell Lysate | HEK293 | Human | Non |
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| ASAP1-1259HF | Recombinant Full Length Human ASAP1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 36 amino acids |
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| ASAP1-472R | Recombinant Rat ASAP1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ASAP1-472R-B | Recombinant Rat ASAP1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ASAP1-772M | Recombinant Mouse ASAP1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| ASAP1-772M-B | Recombinant Mouse ASAP1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ASAP1 involved in several pathways and played different roles in them. We selected most pathways ASAP1 participated on our site, such as Endocytosis,Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | CDC42,KITA,WASL,SRC,CAPZA1,H2-Q10,SH3GL1A,AP2M1A,NEDD4L,ADRB2A |
| Fc gamma R-mediated phagocytosis | PIK3CA,MARCKSL1,PLCG1,PAK1,PLA2G4D,AKT1,VAV1,PRKCD,CFL2,MAPK1 |
Protein Function
ASAP1 has several biochemical functions, for example, GTPase activator activity,metal ion binding,phosphatidylinositol-3,4,5-trisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASAP1 itself. We selected most functions ASAP1 had, and list some proteins which have the same functions with ASAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FGF2,SNAPC3,BOK,PTPN1,PAICS,APLF,CHCHD3,EIF2B1,FBXO25,SRM |
| metal ion binding | NPAS2,ROCK1,CYP2P6,PDE11A,Adcy4,PIR,CDK2,EPX,VSNL1A,MCM10 |
| phosphatidylinositol-3,4,5-trisphosphate binding | OGT,KIF16B,ZFYVE16,AKT1,ARAP2,FAM21C,PARD3,ARHGAP9,ANXA8,RAG2 |
| GTPase activator activity | RIC8B,ARHGAP25,ASAP3,RGS9A,ABR,DOCK2,PLEKHG6,OPHN1,TBC1D24,RGS13 |
| phosphatidylinositol-4,5-bisphosphate binding | SNX20,TULP1,PFN2,MYO1G,Apba1,SNX18,FAM21C,KCNJ1,KLHL8,RS1 |
Interacting Protein
ASAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASAP1.
GRB2;CTTN;SH3KBP1
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References
- Schwenteit, J; Bogdanovic, X; et al. Toxoid construction of AsaP1, a lethal toxic aspzincin metalloendopeptidase of Aeromonas salmonicida subsp achromogenes, and studies of its activity and processing. VETERINARY MICROBIOLOGY 162:687-694(2013).
- Li, HH; Li, Q; et al. WNT1-Inducible Signaling Pathway Protein 1 Contributes to Ventilator-Induced Lung Injury. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 47:528-535(2012).
