ARRB2
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Official Full Name
arrestin, beta 2 -
Overview
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] -
Synonyms
ARRB2;arrestin, beta 2;ARB2;ARR2;BARR2;beta-arrestin-2;arrestin 3;arrestin beta-2
Recombinant Proteins
- Human
- Rat
- Bovine
- E.coli
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- HEK293
- GST
- Non
- N-His-GST
- His
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARRB2-9893H | Recombinant Human ARRB2, GST-tagged | E.coli | Human | GST | 162-408a.a. | |
| ARRB2-26621TH | Recombinant Human ARRB2 | Wheat Germ | Human | Non | 110 amino acids |
|
| ARRb2-3639H | Recombinant Human ARRb2 protein(Asp262~Cys430), His-GST-tagged | E.coli | Human | N-His-GST | Asp262~Cys430 |
|
| ARRB2-803R | Recombinant Rat ARRB2 Protein | Mammalian Cell | Rat | His |
|
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| ARRB2-855H | Recombinant Human ARRB2 protein, GST-tagged | Wheat Germ | Human | GST |
|
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| ARRB2-130HCL | Recombinant Human ARRB2 cell lysate | Human | Non |
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| ARRB2-0340H | Recombinant Human ARRB2 Protein (Met1-Cys409), C-His-tagged | E.coli | Human | His | Met1-Cys409 |
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| ARRB2-0341H | Recombinant Human ARRB2 Protein, Tag Free | E.coli | Human | Non |
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| ARRB2-1247HF | Recombinant Full Length Human ARRB2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 409 amino acids |
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| ARRB2-459R | Recombinant Rat ARRB2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ARRB2-459R-B | Recombinant Rat ARRB2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| ARRB2-631B | Recombinant Bovine ARRB2 protein, His-GST-tagged | E.coli | Bovine | N-His-GST | 240-420aa |
|
Involved Pathway
ARRB2 involved in several pathways and played different roles in them. We selected most pathways ARRB2 participated on our site, such as MAPK signaling pathway,Chemokine signaling pathway,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | PIP5K1A,ZFYVE16,SNX12,RHOAD,EPN2,ACAP3B,KIF5B,TSG101,IGF1RA,SNX3 |
| Olfactory transduction | OR6Q1,OR7C1,GNB1,PRKACB,OR2F1,OR10W1,CALML5,OR51D1,CALML3,PDE1A |
| Dopaminergic synapse | DDC,ITPR3,GNAI1,PPP2R1B,MAOA,GNAQ,ATF4,PPP2R3C,PRKACB,GNB1 |
| Chemokine signaling pathway | PIK3R2,CXCL10,CCL8,LOC100033925,CCL4L1,Cxcl15,PREX1,Ccl21a,CCL25,SHC1 |
| MAPK signaling pathway | TRAF2,MAPK13,MAPK12A,MKNK2B,MAPK12B,NF1,MAP2K7,CACNG7,FGF12A,Fasl |
Protein Function
ARRB2 has several biochemical functions, for example, 14-3-3 protein binding,D1 dopamine receptor binding,G-protein coupled receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARRB2 itself. We selected most functions ARRB2 had, and list some proteins which have the same functions with ARRB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LIMD1,TRIM41,HELLS,RSG1,JAG2,SH3GLB1,RAD23B,COPS7A,BATF2,NUDT4 |
| ubiquitin protein ligase binding | UBE2U,UBE2Z,FAF1,RNF40,BAG6,ABI2,UBE2C,ANAPC2,GPI,HSPA9 |
| alpha-1A adrenergic receptor binding | ARRB1 |
| G-protein coupled receptor binding | HSPA1B,SFTPBB,ARHGEF12,FYN,UCN2,GNA15.1,NPFF,RSPO2,NPB,PSAPL1 |
| type 1 angiotensin receptor binding | JAK2,GNB1,GNA13A,GNA13B,GNG3,GNA13,TYK2,ARAP1,AGT,BDKRB2 |
| protein complex scaffold | TELO2,CAV3,MAGI1,MPP7,WWC3,AXIN1,MAGI1B,AKAP6,DLG1,GNB2L1 |
| protein complex binding | ST13,Ctsl,LCK,ING2,RAP1B,MYC,NASP,RRAS,KRT8,CDKN1A |
| angiotensin receptor binding | DRD1,DRD1A,ARRB1 |
| alpha-1B adrenergic receptor binding | ARRB1,ADRA2A |
Interacting Protein
ARRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARRB2.
MDM2;MAPK9;ARRB1;PPM1B
ARRB2 Related Signal Pathway
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