ARPC1A
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Official Full Name
actin related protein 2/3 complex, subunit 1A, 41kDa -
Overview
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1B. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ARPC1A;actin related protein 2/3 complex, subunit 1A, 41kDa;actin related protein 2/3 complex, subunit 1A (41 kD);actin-related protein 2/3 complex subunit 1A;actin binding protein (Schizosaccharomyces pombe sop2 like);Arc40;SOP2 like protein;SOP2H
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Human Cells
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
ARPC1A involved in several pathways and played different roles in them. We selected most pathways ARPC1A participated on our site, such as Axon guidance,Bacterial invasion of epithelial cells,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARPC1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | KIF4,CEBPB,SEMA4D,UNC5D,KLB,ACTR2,EGR2,CDK8,DPYSL2B,RASGRP1 |
| Axon guidance | AP2A1,SCN3B,PLXNC1,DUSP1,PAK2,NTN4,SEMA3C,EPHA4A,MAPK3,DPYSL2B |
| Endocytosis | TGFBR1A,ARFGAP3,PRKCZ,TGFBR2,GBF1,HSC70,CCR5,TRAF6,FLT1,ARPC3 |
| EPH-Ephrin signaling | EFNA4,EFNA2,KALRN,KALRNB,ITSN1,DNM1,CLTB,SHB,ARPC2,EPHA10 |
| EPHB-mediated forward signaling | EFNB3B,EPHB4A,EFNB2A,ACTR3,EPHB4B,KALRN,ARPC4,EFNB1,ARPC2,EFNB3 |
| Fcgamma receptor (FCGR) dependent phagocytosis | ACTR3,ACTR2,ABI1,WIPF3,MYO1C,IgG3,DOCK1,NCKAP1,ACTR2B,MYO9B |
| Bacterial invasion of epithelial cells | DOCK1,CTTN,ACTB,ARPC2,SEPT3,ARPC5L,MAD2L2,CBLC,CDC42,PIK3R5 |
| Fc gamma R-mediated phagocytosis | WAS,MYO10,PLD2,PPAP2A,PLCG2,PRKCD,RAC2,PTPRC,PLA2G6,PIK3CB |
Protein Function
ARPC1A has several biochemical functions, for example, actin binding,actin filament binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARPC1A itself. We selected most functions ARPC1A had, and list some proteins which have the same functions with ARPC1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| actin binding | EPS8,LSP1,KLHL33,SYN1,UPF3B,MKL1,CFL2L,FER,KIF18A,SMYHC2 |
| actin filament binding | NEXN,CTNNA3,PICK1,LIMA1,SVIL,KLHL17,HIST1H2AH,SYNE3,MYO3A,CTNNA1 |
Interacting Protein
ARPC1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARPC1A here. Most of them are supplied by our site. Hope this information will be useful for your research of ARPC1A.
HACD3;ACTR3B;BAG3;Actb;ACTR2;GRB2;DBN1
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References
- Zucchini, C; Manara, MC; et al. CD99 suppresses osteosarcoma cell migration through inhibition of ROCK2 activity. ONCOGENE 33:1912-1921(2014).
- Chen, CP; Chang, SJ; et al. Prenatal diagnosis and molecular cytogenetic characterization of a de novo interstitial deletion of 7q (7q22.1 -> q31.1). GENE 521:311-315(2013).
