ARNT2
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Official Full Name
aryl-hydrocarbon receptor nuclear translocator 2 -
Overview
This gene encodes a member of the basic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily of transcription factors. The encoded protein acts as a partner for several sensor proteins of the bHLH-PAS family, forming heterodimers with the sensor proteins that bind regulatory DNA sequences in genes responsive to developmental and environmental stimuli. Under hypoxic conditions, the encoded protein complexes with hypoxia-inducible factor 1alpha in the nucleus and this complex binds to hypoxia-responsive elements in enhancers and promoters of oxygen-responsive genes. A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. -
Synonyms
ARNT2;aryl-hydrocarbon receptor nuclear translocator 2;aryl hydrocarbon receptor nuclear translocator 2;bHLHe1;KIAA0307;ARNT protein 2;class E basic helix-loop-helix protein 1
Recombinant Proteins
- Mouse
- Rat
- Human
- Zebrafish
- Mammalian Cell
- Wheat Germ
- HEK293
- E.coli
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
ARNT2 involved in several pathways and played different roles in them. We selected most pathways ARNT2 participated on our site, such as Pathways in cancer,Transcriptional misregulation in cancer,Renal cell carcinoma, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARNT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Renal cell carcinoma | PAK6,TCEB1,ETS1,ARNT,VEGFA,MAP2K1,TCEB2,EGLN1,TGFA,AKT2 |
| Transcriptional misregulation in cancer | TRP53,H3F3B,ELANE,ITGB7,GZMB,DOT1L,HOXA10,GOLPH3L,MMP9,RUNX1 |
| Pathways in cancer | TGFB1,RARA,LPAR5,FGF12,ITGAV,TRAF2,FGF21,PRKACG,ITGB1,RUNX1T1 |
Protein Function
ARNT2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,aryl hydrocarbon receptor binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARNT2 itself. We selected most functions ARNT2 had, and list some proteins which have the same functions with ARNT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | FOXN2,MAX,ZGPAT,NFE2L2B,ARNTL1A,MYBL2,TEAD1A,ZNF35,NR1I3,AHR |
| aryl hydrocarbon receptor binding | AIP,ARNTL,ARNT |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | ESRRA,KLF5,FOSL1,POU3F2,TFE3B,RAX,TP73,Ar,CTCFL,NR5A2 |
| protein heterodimerization activity | IL12A,CD3G,SLC51A,SDCBP2,TAS1R2,BCL2L2,RALGAPA1,NFKB1,HIST1H4F,SOX15 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | HAND1,SFPI1,TFAP2E,ZNF713,JUN,FOS,HELT,MYC,HNRNPK,SMAD4 |
Interacting Protein
ARNT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARNT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARNT2.
TAX1BP3;USP7;SH3GL2;BCL6
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