ARL2BP
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Official Full Name
ADP-ribosylation factor-like 2 binding protein -
Overview
ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. -
Synonyms
ARL2BP;ADP-ribosylation factor-like 2 binding protein;ADP-ribosylation factor-like protein 2-binding protein;BART;BART1;binder of Arl2;ADP ribosylation factor like 2 binding protein;Arf like 2 binding protein BART1;ARL2BP protein;Binder of Arl Two;binder of ARF2 protein 1;ARF-like 2-binding protein;Arf-like 2 binding protein BART1
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- Cynomolgus
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- His&Fc
- Non
- His&Fc&Avi
Involved Pathway
ARL2BP involved in several pathways and played different roles in them. We selected most pathways ARL2BP participated on our site, such as Integration of energy metabolism,Metabolism,Regulation of insulin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARL2BP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | FTCD,SLC23A2,DPEP1,NUDT3,CTH,HSD17B11,ALOX5B.2,KIAA1199,CYGB1,ABHD3 |
| Regulation of insulin secretion | MARCKSB,KCNC2,MARCKSA,KCNS3,ARL2,KCNS3A,KCNB1,SYT5 |
| Integration of energy metabolism | RAPGEF3,MARCKSB,GNB5A,SYT5,ARL2,GNG13B,KCNC2,MARCKSA,AKAP5,GNG13A |
Protein Function
ARL2BP has several biochemical functions, for example, GTPase regulator activity,protein binding,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARL2BP itself. We selected most functions ARL2BP had, and list some proteins which have the same functions with ARL2BP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase regulator activity | PCP2,RHPN1,GPSM2,RGS14A,RALGDS,RIMS1,TSC1B,KRIT1,WAS,TSC1 |
| transcription coactivator activity | RFXAP,DDX17,MAML1,NR1H4,CTNNB1,ESR2,CREBBP,TAF7,MED31,WNT3A |
| protein binding | SHMT1,PFDN4,HMGA2,SIRPG,RRM1,SEC22A,KAZN,HIST1H4B,KLK13,TNKS2 |
Interacting Protein
ARL2BP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARL2BP here. Most of them are supplied by our site. Hope this information will be useful for your research of ARL2BP.
ARL2;RAC1;MPP3;CAMK2D
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References
- Davidson, AE; Schwarz, N; et al. Mutations in ARL2BP, Encoding ADP-Ribosylation-Factor-Like 2 Binding Protein, Cause Autosomal-Recessive Retinitis Pigmentosa. AMERICAN JOURNAL OF HUMAN GENETICS 93:321-329(2013).
- Zhou, Y; Jiang, H; et al. MicroRNA-195 targets ADP-ribosylation factor-like protein 2 to induce apoptosis in human embryonic stem cell-derived neural progenitor cells. CELL DEATH & DISEASE 4:-(2013).
