ARHGEF6
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Official Full Name
Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -
Overview
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. -
Synonyms
ARHGEF6;Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6;mental retardation, X linked 46 , MRX46;rho guanine nucleotide exchange factor 6;alpha PIX;alphaPIX;Cool 2;Cool2;KIAA0006;PAK interacting exchange factor;alpha;Rac/Cdc42 guanine exchange factor (GEF) 6;Mental retardation, X linked 46;MRX46;PAK interacting exchange factor alpha;PIXA;Rac/cdc42 guanine nucleotide exchange factor 6;PAK-interacting exchange factor alpha;PAK-interacting exchange factor, alpha;Cool-2;alpha-PIX
Recombinant Proteins
- Chicken
- Rhesus macaque
- Rat
- Human
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- HEK293
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARHGEF6-1573C | Recombinant Chicken ARHGEF6 | Mammalian Cell | Chicken | His |
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| ARHGEF6-395R | Recombinant Rhesus monkey ARHGEF6 Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| ARHGEF6-773R | Recombinant Rat ARHGEF6 Protein | Mammalian Cell | Rat | His |
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| ARHGEF6-789H | Recombinant Human ARHGEF6 protein, GST-tagged | Wheat Germ | Human | GST |
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| ARHGEF6-119HCL | Recombinant Human ARHGEF6 cell lysate | Human | Non |
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| ARHGEF6-1133HF | Recombinant Full Length Human ARHGEF6 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 776 amino acids |
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| ARHGEF6-224R | Recombinant Rhesus Macaque ARHGEF6 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| ARHGEF6-224R-B | Recombinant Rhesus Macaque ARHGEF6 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| ARHGEF6-429R | Recombinant Rat ARHGEF6 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| ARHGEF6-429R-B | Recombinant Rat ARHGEF6 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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Involved Pathway
ARHGEF6 involved in several pathways and played different roles in them. We selected most pathways ARHGEF6 participated on our site, such as Regulation of actin cytoskeleton,Pancreatic cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | INSB,ARHGEF7A,ITGB4,BCAR1,VAV3,CD14,INS,APC,ARPC4L,INSRR |
| Pancreatic cancer | RALB,BAD,TGFB3,RB1,KRAS,RALGDS,PIK3R2,RALBP1,STAT1,RAF1 |
Protein Function
ARHGEF6 has several biochemical functions, for example, GTPase activator activity,Rho guanyl-nucleotide exchange factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF6 itself. We selected most functions ARHGEF6 had, and list some proteins which have the same functions with ARHGEF6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | THRA,NEUROG1,CKS1B,ATP6V0D1,ZHX1,RFX1,APOBEC3H,IGFL1,PIK3R6,SGOL1 |
| GTPase activator activity | TBC1D3B,ARHGAP12,ARHGAP22,DOCK1,ARHGAP19,RABEP1,TBC1D8B,CDC42EP5,RAP1GAP2B,RASAL1 |
| Rho guanyl-nucleotide exchange factor activity | ARHGEF2,ARHGEF1B,ARHGEF3,ARHGEF16,FGD1,ARHGEF15,FGD6,DOCK11,DOCK9,FGD3 |
Interacting Protein
ARHGEF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF6.
PAK1;NAA10;PAK2;SH2D1A;CDC42;MDM2;ADAM15;nef;TMEM108;GPRASP2;SH3GL3;ZNF580;q9wmx2-pro_0000037548;GIT1;ARRB2
Resources
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References
- Estrach, S; Schmidt, S; et al. The human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth. CURRENT BIOLOGY 12:307-312(2002).
