ARHGEF3

  • Official Full Name

    Rho guanine nucleotide exchange factor (GEF) 3
  • Overview

    Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ARHGEF3;Rho guanine nucleotide exchange factor (GEF) 3;rho guanine nucleotide exchange factor 3;DKFZP434F2429;exchange factor found in platelets and leukemic and neuronal tissues;XPLN;GEF3;RhoGEF protein;STA3;59.8 kDA protein;ARHGEF 3;Exchange factor found in platelets and leukemic and neuronal tissues XPLN;FLJ98126;GEF 3;MGC118905;STA 3;exchange factor found in platelets and leukemic and neuronal tissues, XPLN

Recombinant Proteins

  • Mouse
  • Chicken
  • Zebrafish
  • Human
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
ARHGEF3-1898M Recombinant Mouse ARHGEF3 Protein Mammalian Cells Mouse His
ARHGEF3-2308C Recombinant Chicken ARHGEF3 Mammalian Cells Chicken His
ARHGEF3-5258Z Recombinant Zebrafish ARHGEF3 Mammalian Cells Zebrafish His
ARHGEF3-786H Recombinant Human ARHGEF3 protein, GST-tagged Wheat Germ Human GST
ARHGEF3-8731HCL Recombinant Human ARHGEF3 293 Cell Lysate HEK293 Human Non
ARHGEF3-1238HF Recombinant Full Length Human ARHGEF3 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 324 amino acids
ARHGEF3-697M Recombinant Mouse ARHGEF3 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
ARHGEF3-697M-B Recombinant Mouse ARHGEF3 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ARHGEF3 involved in several pathways and played different roles in them. We selected most pathways ARHGEF3 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE,G alpha (12/13) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rho GTPase cycle RHOT1A,FGD2,RHOU,DEPDC1B,TAGAPA,OBSCN,FAM13B1,ARHGAP29B,MYO9B,TAGAP1
    Regulation of RhoA activity ARHGAP4,MYO9B,ARHGEF10L,FARP1,ARHGEF15,AKAP13,PLEKHG6,NET1,ARHGEF25,ABR
    GPCR downstream signaling RGS17,EDN1,RGS18,OR56A1,KALRN,GPR65,NMU,PROK1,TIAM2,GPR132
    Signaling by GPCR PROK1,RGS7,OR56A1,OR10A5,OPN5,UTS2D,OXGR1A.2,CCK,FGD4A,ARHGEF18
    G alpha (12/13) signalling events ARHGEF18A,ARHGEF18,ARHGEF17,ARHGEF9,FGD4A,ARHGEF1A,RHOB,TRIO,RHOAE,FGD2
    Signal Transduction FABP11A,FGD4,ARHGAP18,ANXA1B,ARHGEF16,NTS,RDH13,PTPRUB,DLK1,AES
    NRAGE signals death through JNK ARHGEF18,ABR,ARHGEF16,OBSCN,ARHGAP4,MCF2L,ARHGEF9,ARHGEF18A,FGD4A,AATF
    Cell death signalling via NRAGE, NRIF and NADE ARHGEF16,ARHGEF18A,ARHGEF17,ECT2,ARHGEF9,ITSN1,ARHGAP4A,ABR,FGD2,MCF2L

    Protein Function

    ARHGEF3 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF3 itself. We selected most functions ARHGEF3 had, and list some proteins which have the same functions with ARHGEF3. You can find most of the proteins on our site.

    Function Related Protein
    Rho guanyl-nucleotide exchange factor activity RASGRF2,DOCK11,PLEKHG7,ARHGEF39,PREX1,TRIOA,ARHGEF33,KALRNB,ARHGEF9B,VAV3
    protein binding LPHN1,LGALS8,ERLIN1,BCL2,DOCK2,SNAPC5,PIP5K1C,SPRYD7,ZFP335,DPPA4

    Interacting Protein

    ARHGEF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF3.

    TRIM27;TRIM23;CEP70

    Resources

    References

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