ARHGEF28

  • Official Full Name

    Rho guanine nucleotide exchange factor (GEF) 28

  • Overview

    This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.

  • Synonyms

    ARHGEF28;RIP2;RGNEF;p190RHOGEF;Rho guanine nucleotide exchange factor (GEF) 28;rho guanine nucleotide exchange factor 28;p190-RhoGEF;Rho interacting protein 2;rho-guanine nucleotide exchange factor;190 kDa guanine nucleotide exchange factor
Cat.# Product name Source (Host) Species Tag Protein Length Price
ARHGEF28-540HCL Recombinant Human ARHGEF28 lysate HEK293 Human Non

    Involved Pathway

    ARHGEF28 involved in several pathways and played different roles in them. We selected most pathways ARHGEF28 participated on our site, such as Axon guidance,Developmental Biology,EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF28 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance PAQR3A,COL9A1B,NFATC2,EFNB2A,TRPC5,RGS3,RASA1,AGRN,SEMA5A,NTN4
    Signaling events mediated by focal adhesion kinase ARHGAP26,KLF8,ACTA1,BMX
    Developmental Biology FRS2B,EFNA2A,EPHB4A,COL6A3,TRPC3,ADAM22,EFNA4,TRPC5,TCF3B,CNTN6
    EPH-Ephrin signaling CLTB,ARPC1A,EPHA10,AP2A2,EPHA4A,KALRNB,DNM1,ARPC3,KDR,EPHB3A
    EPHB-mediated forward signaling EPHB4B,EFNB3,ARPC3,ITSN1,EFNB2A,ACTR3,ARPC5,EPHB4A,EFNB1,KALRN
    Regulation of RhoA activity FARP1,ARHGEF10,ARHGEF25,PLEKHG6,ARHGAP4,AKAP13,OBSCN,DLC1,ARHGEF15,MYO9B

    Protein Function

    ARHGEF28 has several biochemical functions, for example, RNA binding,Rho guanyl-nucleotide exchange factor activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF28 itself. We selected most functions ARHGEF28 had, and list some proteins which have the same functions with ARHGEF28. You can find most of the proteins on our site.

    Function Related Protein
    Rho guanyl-nucleotide exchange factor activity KALRNB,AKAP13,ITSN2A,ARHGEF2,ARHGEF1,ARHGEF33,TRIOA,FGD4A,FARP2,DOCK11
    metal ion binding FOXP4,UGP2,Fcer2a,ZFR,EXO1,BHLHE22,EPX,UNC13C,PDE1A,AGFG1
    RNA binding APOBEC2,ATXN1L,FXR2,RAE1,ZRANB2,CPSF2,CPEB1B,IFIT3,DIS3L,FUS

    Interacting Protein

    ARHGEF28 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF28 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF28.

    q9wmx2-pro_0000037548

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