ARHGEF25

  • Official Full Name

    Rho guanine nucleotide exchange factor (GEF) 25

  • Overview

    Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP;exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in;contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation.;Multiple transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    ARHGEF25;Rho guanine nucleotide exchange factor (GEF) 25;rho guanine nucleotide exchange factor 25;GEFT;p63RhoGEF;RAC/CDC42 exchange factor;Rac/Cdc42/Rho exchange factor GEFT;RhoA/RAC/CDC42 exchange factor;RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT;guanine nucleotide exchange factor GEFT

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cell
  • HEK293
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ARHGEF25-1896M Recombinant Mouse ARHGEF25 Protein Mammalian Cell Mouse His
ARHGEF25-771R Recombinant Rat ARHGEF25 Protein Mammalian Cell Rat His
ARHGEF25-975H Recombinant Human ARHGEF25 Mammalian Cell Human His
ARHGEF25-5962HCL Recombinant Human GEFT 293 Cell Lysate HEK293 Human Non
ARHGEF25-2497H Recombinant Human ARHGEF25 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
ARHGEF25-2497H-B Recombinant Human ARHGEF25 Protein Pre-coupled Magnetic Beads HEK293 Human
ARHGEF25-427R Recombinant Rat ARHGEF25 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
ARHGEF25-427R-B Recombinant Rat ARHGEF25 Protein Pre-coupled Magnetic Beads HEK293 Rat
ARHGEF25-696M Recombinant Mouse ARHGEF25 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ARHGEF25-696M-B Recombinant Mouse ARHGEF25 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ARHGEF25 involved in several pathways and played different roles in them. We selected most pathways ARHGEF25 participated on our site, such as G alpha (q) signalling events,GPCR downstream signaling,Gastrin-CREB signalling pathway via PKC and MAPK, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gastrin-CREB signalling pathway via PKC and MAPK NPS,NPFFR2,QRFP,NPSR1,LPAR5A,EDN3,GRP,GCGA,OPN4,GPR65
    Regulation of RAC1 activity SPATA13,ARHGAP1,RALBP1,ARHGAP17,CHN2,RAP1GDS1,DEF6,ABR,CHN1,EPS8
    G alpha (q) signalling events PROKR2,NMS,GRP,TRPC3,GPRC6A,CHRM5,UTS2D,TAC3,PRKCHB,GPR132B
    Regulation of CDC42 activity DOCK9,ARHGAP17,BCAR3,DNMBP,DOCK10,SPATA13,RALBP1,DOCK6,ARHGAP1,MCF2L
    Signal Transduction SCT,PYY,RGS9BP,GMIP,HHAT,NRP2B,OPN1LW1,HCRT,RHOT1A,RBP2A
    GPCR downstream signaling SST1.1,PTHLHA,ARHGEF9,ADORA1,RAMP3,TRPC7,DGKG,OPN5,SOUL4,RGS18
    Regulation of RhoA activity PLEKHG6,ARHGEF18,ARHGAP4,ARAP1,MYO9B,ARHGAP9,ECT2,ARHGEF3,OBSCN,AKAP13
    Signaling by GPCR PTHRP2,OR2AP1,OXGR1,MLN,ADCYAP1B,CD97,CCL35.2,CCRL2,OXGR1A.2,ADM2A

    Protein Function

    ARHGEF25 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF25 itself. We selected most functions ARHGEF25 had, and list some proteins which have the same functions with ARHGEF25. You can find most of the proteins on our site.

    Function Related Protein
    Rho guanyl-nucleotide exchange factor activity DCLRE1B,ARHGEF3,ARHGEF18A,QUO,PLEKHG3,VAV3,FGD4A,ARHGEF1B,ARHGEF10,ARHGEF10L

    Interacting Protein

    ARHGEF25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF25 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF25.

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