ARHGEF15
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Official Full Name
Rho guanine nucleotide exchange factor (GEF) 15 -
Overview
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. -
Synonyms
ARHGEF15;Rho guanine nucleotide exchange factor (GEF) 15;rho guanine nucleotide exchange factor 15;ARGEF15;FLJ13791;KIAA0915;MGC44868;Rho guanine exchange factor (GEF) 15;Vsm RhoGEF;ephexin-5;Rho GEF 15;E5;Ephexin5;Vsm-RhoGEF
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARHGEF15-889H | Recombinant Human ARHGEF15 | Mammalian Cell | Human | His |
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| ARHGEF15-8733HCL | Recombinant Human ARHGEF15 293 Cell Lysate | HEK293 | Human | Non |
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| Arhgef15-1692M | Recombinant Mouse Arhgef15 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| ARHGEF15-2496H | Recombinant Human ARHGEF15 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| ARHGEF15-2496H-B | Recombinant Human ARHGEF15 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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Involved Pathway
ARHGEF15 involved in several pathways and played different roles in them. We selected most pathways ARHGEF15 participated on our site, such as EPHA forward signaling,Regulation of RhoA activity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of RhoA activity | ABR,ARHGEF10L,ARHGEF28,ARHGEF3,ECT2,ARHGEF25,ARHGEF18,NET1,OBSCN,PLEKHG6 |
| EPHA forward signaling | EFNA1,EPHA2,EFNA5,CRKL,EFNA3,EFNA2,BLK |
Protein Function
ARHGEF15 has several biochemical functions, for example, GTPase activator activity,Rho guanyl-nucleotide exchange factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF15 itself. We selected most functions ARHGEF15 had, and list some proteins which have the same functions with ARHGEF15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | SMAP1,TBC1D9,RGS6,ARFGAP1,RAB3GAP2,OPHN1,RGS14,TBC1D20,TIAM2,ASAP2B |
| Rho guanyl-nucleotide exchange factor activity | DOCK11,ITSN1,KALRNB,ARHGEF3,TIAM2,DCLRE1B,ARHGEF9,PLEKHG4,RASGRF2B,VAV2 |
| protein binding | PLEKHG6,AMDHD2,ARHGEF38,PDGFRA,SH3PXD2A,SERPINF1,TAOK1,RP9,PRKAA2,TUBGCP4 |
Interacting Protein
ARHGEF15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF15.
C11orf49;MOB4
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