ARHGEF1

  • Official Full Name

    Rho guanine nucleotide exchange factor (GEF) 1

  • Overview

    Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that;work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate;Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the;full-length nature of some variants has not been defined.

  • Synonyms

    ARHGEF1;Rho guanine nucleotide exchange factor (GEF) 1;rho guanine nucleotide exchange factor 1;LBCL2;P115 RHOGEF;SUB1.5;115 kD protein;115 kDa guanine nucleotide exchange factor;ARHGEF 1;GEF 1;GEF1;LBCL 2;Lsc homolog;p115RhoGEF;115-kD protein;LSC;P115-RHOGEF

Recombinant Proteins

  • Mouse
  • Human
  • Mammalian Cell
  • E.coli
  • Wheat Germ
  • In Vitro Cell Free System
  • HEK293T
  • HEK293
  • His
  • GST
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
ARHGEF1-1886M Recombinant Mouse ARHGEF1 Protein Mammalian Cell Mouse His
ARHGEF1-27183TH Recombinant Human ARHGEF1, His-tagged E.coli Human His 491-655 a.a.
ARHGEF1-777H Recombinant Human ARHGEF1 protein, GST-tagged Wheat Germ Human GST
ARHGEF1-1092HF Recombinant Full Length Human ARHGEF1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 912 amino acids
Arhgef1-1298M Recombinant Mouse Arhgef1 Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK
ARHGEF1-2699H Recombinant Human ARHGEF1 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
ARHGEF1-6362H Recombinant Human ARHGEF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
ARHGEF1-690M Recombinant Mouse ARHGEF1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
ARHGEF1-690M-B Recombinant Mouse ARHGEF1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    ARHGEF1 involved in several pathways and played different roles in them. We selected most pathways ARHGEF1 participated on our site, such as Vascular smooth muscle contraction,Platelet activation,Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGEF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Regulation of Actin Cytoskeleton PIK3R1,SRC,PIP5K1BB,FGD,PAK6B,PIKFYVE,FGFR3,PDGFRA,WASLB,EZRB
    Vascular smooth muscle contraction BRAF,ROCK2B,PPP1R14AB,PPP1CC,MAP2K2,GNA13A,GUCY1A3,CYP4A12A,ADRA1BB,CALML5
    Platelet activation ARHGAP35,PRKACB,PLCB3,FCER1G,GNAI1,MAPK1,MAPK13,PIK3CA,PLA2G4A,GNAI2
    Pathways in cancer CASP8,PLEKHG5,MMP1A,BCR,CCND1,FAS,IGF1,FGF19,ERBB2,PRKCG
    Proteoglycans in cancer MAPK3,Fasl,ANK1,COL21A1,MAPK1,WNT7B,TNF,IGF2,HCLS1,SDC1

    Protein Function

    ARHGEF1 has several biochemical functions, for example, GTPase activator activity,Rho guanyl-nucleotide exchange factor activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGEF1 itself. We selected most functions ARHGEF1 had, and list some proteins which have the same functions with ARHGEF1. You can find most of the proteins on our site.

    Function Related Protein
    Rho guanyl-nucleotide exchange factor activity ARHGEF39,C3A.1,PLEKHG4,ARHGEF11,FGD4A,FGD5,PREX1,ARHGEF28,TRIO,ALS2CL
    poly(A) RNA binding RPL35,MBNL3,IFIT2,MTERF,SLIRP,CCDC55,RPS14,S100A16,RPLP0,RPS24
    protein binding SUSD2,ARID3A,DNAJB6,KRT38,GSK3B,CCNK,HLA-DRB4,ANXA1,FNBP4,TRIP13
    GTPase activator activity RGS7,ARHGAP28,PLEKHG6,PREX2,ARHGDIA,AGFG1A,ACAP1,ALDH1A2,TBC1D15,ARRB1

    Interacting Protein

    ARHGEF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGEF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGEF1.

    q7db74_eco57;TCF4;GNA13;q81y32_bacan;CSNK1E;RHOB;SREBF2;mhpD1;iolA2;pi3p

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