ARHGAP6
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Official Full Name
Rho GTPase activating protein 6 -
Overview
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ARHGAP6;Rho GTPase activating protein 6;rho GTPase-activating protein 6;rhoGAPX 1;ARHGAP 6;Rho type GTPase activating protein RhoGAPX 1;RHOGAP 6;RHOGAP6;RhoGAPX1;OTTHUMP00000022913;OTTHUMP00000022915;OTTHUMP00000022916;OTTHUMP00000022917;OTTHUMP00000022918;OTTHUMP00000236431;rho-type GTPase-activating protein 6;Rho-type GTPase-activating protein RhoGAPX-1;RHOGAPX-1
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Mammalian Cells
- Wheat Germ
- HEK293
- His
- GST
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARHGAP6-1880M | Recombinant Mouse ARHGAP6 Protein | Mammalian Cells | Mouse | His |
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| ARHGAP6-4011Z | Recombinant Zebrafish ARHGAP6 | Mammalian Cells | Zebrafish | His |
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| ARHGAP6-772H | Recombinant Human ARHGAP6 protein, GST-tagged | Wheat Germ | Human | GST |
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| ARHGAP6-2704H | Recombinant Human ARHGAP6 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| ARHGAP6-4452H | Recombinant Human ARHGAP6 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| Arhgap6-645M | Recombinant Mouse Arhgap6 Protein, MYC/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| ARHGAP6-686M | Recombinant Mouse ARHGAP6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| ARHGAP6-686M-B | Recombinant Mouse ARHGAP6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
ARHGAP6 involved in several pathways and played different roles in them. We selected most pathways ARHGAP6 participated on our site, such as Rho GTPase cycle,Signal Transduction,Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by Rho GTPases | LIN7B,ARHGAP17A,MYO9B,ARHGAP22,PLEKHG2,ARHGAP17,PRC1,KTN1,ARHGAP32,ARHGAP29B |
| Signal Transduction | EVC2,LRIG1,USP15,NEDD8,RLBP1A,IQGAP3,SHARPIN,RAMP2,WDR35,TAX1BP1 |
| Rho GTPase cycle | ARHGAP19,RHOJ,ARHGAP25,CHN2,ARHGEF18,OBSCN,ARHGAP40,ARHGAP18,TAGAPA,NET1 |
Protein Function
ARHGAP6 has several biochemical functions, for example, GTPase activator activity,SH3 domain binding,phospholipase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP6 itself. We selected most functions ARHGAP6 had, and list some proteins which have the same functions with ARHGAP6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | QKIA,OSTF1,INPPL1B,CD2AP,WAS,CRB3,REPS1,PDCD6IP,SH2D2A,DNAJC6 |
| GTPase activator activity | ARHGAP20,STARD8,RGS20,STXBP5A,ELMOD1,DEPDC1B,RAP1GAP,RGS5B,ACAP3,TBC1D26 |
| phospholipase activator activity | CCL5,PDPK1,CCL8,GM2A,APOC2,CCL3 |
| phospholipase binding | CALM2,SERPINB1A,NEFL,LMNB1,PRKCZ,WAS,DGKQ,Pla2r1,PDPK1,CALM1 |
Interacting Protein
ARHGAP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP6.
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