ARHGAP5
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Official Full Name
Rho GTPase activating protein 5 -
Overview
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ARHGAP5;Rho GTPase activating protein 5;GFI2, growth factor independent 2;rho GTPase-activating protein 5;p190 B;p190BRhoGAP;RhoGAP5;ARHGAP 5;p190 RhoGAP;RhoGAP 5;RhoGAP;p105 RhoGAP;OTTHUMP00000244094;OTTHUMP00000244095;OTTHUMP00000244097;OTTHUMP00000244099;growth factor independent 2;p100 RasGAP-associated p105 protein;rho-type GTPase-activating protein 5;GFI2;p190-B
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARHGAP5-393R | Recombinant Rhesus monkey ARHGAP5 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| ARHGAP5-8737HCL | Recombinant Human ARHGAP5 293 Cell Lysate | HEK293 | Human | Non |
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| ARHGAP5-222R | Recombinant Rhesus Macaque ARHGAP5 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| ARHGAP5-222R-B | Recombinant Rhesus Macaque ARHGAP5 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
ARHGAP5 involved in several pathways and played different roles in them. We selected most pathways ARHGAP5 participated on our site, such as Focal adhesion,Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leukocyte transendothelial migration | NCF2,Itgam&Itgb2,CLDN18,ITGB2,F11R,ITGB2L,GNAI2,THY1,MSN,CLDN17 |
| Focal adhesion | BCL2,VAV1,PDGFRA,COL27A1,FLT1,CAPN2L,ACTG1,RAC1A,RAC3A,PIP5K1C |
Protein Function
ARHGAP5 has several biochemical functions, for example, GTP binding,GTPase activator activity,GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP5 itself. We selected most functions ARHGAP5 had, and list some proteins which have the same functions with ARHGAP5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | TBC1D22A,ACAP3,TBC1D30,CHN2,SGSM2,RGS21,ALDH1A1,RGS4,TBC1D20,CDC42EP2 |
| protein binding | BANF1,GHITM,PGR,UNC119B,KIF18B,SAE1,CAP2,RAD51C,SEMA7A,C2orf62 |
| GTP binding | ARFRP1,SEPT11,GUCY1B3,PCK1,RAB44,ATL2,RAB1BB,ARFIP2,RHOBTB2,RAB7 |
| SH2 domain binding | MS4A2,NUP62,SH3PXD2B,SYP,INPPL1,PTK2,CTR9,LILRB1,LAT2,AFAP1L2 |
| GTPase activity | RAB40A,RAC1,RAB6C,RAP1GAP,RAB10,RAB11AL,DNAJC27,GNAI2A,RAB28,TUBA8L4 |
Interacting Protein
ARHGAP5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP5.
Rnd3;SMURF2
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References
- Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).
- Zhang, QP; Zhang, HY; et al. srGAP3 promotes neurite outgrowth of dorsal root ganglion neurons by inactivating RAC1. ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE 7:630-638(2014).
