ARHGAP26
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Official Full Name
Rho GTPase activating protein 26 -
Overview
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ARHGAP26;Rho GTPase activating protein 26;rho GTPase-activating protein 26;GRAF;GTPase regulator associated with the focal adhesion kinase pp125;KIAA0621;OPHN1L;OPHN1L1;oligophrenin-1-like protein;GTPase regulator associated with focal adhesion k
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293T
- In Vitro Cell Free System
- HEK293
- His
- GST
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ARHGAP26-9822H | Recombinant Human ARHGAP2, His-tagged | E.coli | Human | His | 403--759a.a. | |
| ARHGAP26-6748C | Recombinant Chicken ARHGAP26 | Mammalian Cell | Chicken | His |
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| ARHGAP26-767H | Recombinant Human ARHGAP26 protein, GST-tagged | Wheat Germ | Human | GST |
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| ARHGAP26-111HCL | Recombinant Human ARHGAP26 cell lysate | Human | Non |
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| ARHGAP26-1145H | Recombinant Human ARHGAP26 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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| ARHGAP26-1193HF | Recombinant Full Length Human ARHGAP26 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 759 amino acids |
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| Arhgap26-1684M | Recombinant Mouse Arhgap26 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| ARHGAP26-2514H | Recombinant Human ARHGAP26 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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Involved Pathway
ARHGAP26 involved in several pathways and played different roles in them. We selected most pathways ARHGAP26 participated on our site, such as Rho GTPase cycle,Signal Transduction,Signaling by Rho GTPases, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP26 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling events mediated by focal adhesion kinase | ARHGEF28,KLF8,ACTA1,BMX |
| Signal Transduction | GPR161,SOX13,RNF43,RARGA,QRFP,CCL19A.2,INSL5,DNER,CRABP2A,RHOV |
| Rho GTPase cycle | ARHGAP23,AKAP13,ARHGEF18,OBSCN,TAGAPB,NET1,ARHGAP15,FAM13B1,RHOT1B,ARHGAP32 |
| Signaling by Rho GTPases | ARAP2,KIF14,RTKN,GMIP,ARHGAP32,MKL1B,RHOT1B,FAM13B,ARHGAP25,NF2A |
Protein Function
ARHGAP26 has several biochemical functions, for example, GTPase activator activity,phospholipid binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP26 itself. We selected most functions ARHGAP26 had, and list some proteins which have the same functions with ARHGAP26. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LAIR1,AIG1,FAM82A2,RBM26,H2AFZ,NSUN4,COA3,LGI4,NLRC4,MYCN |
| phospholipid binding | OSBPL1A,CPS1,PRKCI,FABP1,PLEKHA3,PSD2,NR5A2,GLTPD1,PICALMA,MYOF |
| GTPase activator activity | ARHGAP25,TBC1D22A,RABGAP1,ARHGAP8,RAP1GAP,GNAQ,AGAP1,STARD13,RASA4,GDI1 |
Interacting Protein
ARHGAP26 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP26 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP26.
PKN3;CDC42EP2;apc;SRPK1;Nyap1;Nyap2;MYO16
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References
- Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).
- Hasler, SLA; Vallis, Y; et al. GRAF1a is a brain-specific protein that promotes lipid droplet clustering and growth, and is enriched at lipid droplet junctions. JOURNAL OF CELL SCIENCE 127:4602-4619(2014).
